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Interleukin 27R regulates CD4(+) T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

CD4(+) T cells mediate protection against Mycobacterium tuberculosis (Mtb); however, the phenotype of protective T cells is undefined, thereby confounding vaccination efforts. IL-27 is highly expressed during human tuberculosis (TB), and absence of IL-27R (Il27ra) specifically on T cells results in...

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Detalles Bibliográficos
Autores principales:	Torrado, Egidio, Fountain, Jeffrey J., Liao, Mingfeng, Tighe, Michael, Reiley, William W., Lai, Rachel P., Meintjes, Graeme, Pearl, John E., Chen, Xinchun, Zak, Daniel E., Thompson, Ethan G., Aderem, Alan, Ghilardi, Nico, Solache, Alejandra, McKinstry, K. Kai, Strutt, Tara M., Wilkinson, Robert J., Swain, Susan L., Cooper, Andrea M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548054/ https://www.ncbi.nlm.nih.gov/pubmed/26282876 http://dx.doi.org/10.1084/jem.20141520

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