CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability

The CCR4–NOT deadenylase complex plays crucial roles in mRNA decay and translational repression induced by poly(A) tail shortening. Although the in vitro activities of each component of this complex have been well characterized, its in vivo role in immune cells remains unclear. Here we show that mic...

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Detalles Bibliográficos
Autores principales: Inoue, Takeshi, Morita, Masahiro, Hijikata, Atsushi, Fukuda-Yuzawa, Yoko, Adachi, Shungo, Isono, Kyoichi, Ikawa, Tomokatsu, Kawamoto, Hiroshi, Koseki, Haruhiko, Natsume, Tohru, Fukao, Taro, Ohara, Osamu, Yamamoto, Tadashi, Kurosaki, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548056/
https://www.ncbi.nlm.nih.gov/pubmed/26238124
http://dx.doi.org/10.1084/jem.20150384

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