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Functional IRF3 deficiency in a patient with herpes simplex encephalitis

Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel genetic etiology of HSE by identifying a heterozygous loss-of-function mutation in the IFN regulatory factor 3 (IRF3...

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Detalles Bibliográficos
Autores principales:	Andersen, Line Lykke, Mørk, Nanna, Reinert, Line S., Kofod-Olsen, Emil, Narita, Ryo, Jørgensen, Sofie E., Skipper, Kristian A., Höning, Klara, Gad, Hans Henrik, Østergaard, Lars, Ørntoft, Torben F., Hornung, Veit, Paludan, Søren R., Mikkelsen, Jacob Giehm, Fujita, Takashi, Christiansen, Mette, Hartmann, Rune, Mogensen, Trine H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548062/ https://www.ncbi.nlm.nih.gov/pubmed/26216125 http://dx.doi.org/10.1084/jem.20142274

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