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The Prognostic Value of Pyrosequencing-Detected MGMT Promoter Hypermethylation in Newly Diagnosed Patients with Glioblastoma
O6-methylguanine-DNA-methyltransferase (MGMT) has emerged as a relevant predictor of therapeutic response and good prognosis in patients with glioblastoma (GBM). Transcriptionally active MGMT rapidly removes the alkyl adducts, preventing the formation of cross-links and thereby causing resistance to...
Autores principales: | Villani, Veronica, Casini, Beatrice, Pace, Andrea, Prosperini, Luca, Carapella, Carmine M., Vidiri, Antonello, Fabi, Alessandra, Carosi, Mariantonia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548097/ https://www.ncbi.nlm.nih.gov/pubmed/26347581 http://dx.doi.org/10.1155/2015/604719 |
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