Cargando…

Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS

We have characterized the nuclear localization signal (NLS) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging. Crystallography and binding studies confirm the bipartite nature of the XRCC1 NLS interaction with Importin α (Impα) in which the major and minor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kirby, Thomas W., Gassman, Natalie R., Smith, Cassandra E., Pedersen, Lars C., Gabel, Scott A., Sobhany, Mack, Wilson, Samuel H., London, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548243/ https://www.ncbi.nlm.nih.gov/pubmed/26304019 http://dx.doi.org/10.1038/srep13405

Ejemplares similares

Characterization of Ku702–NLS as Bipartite Nuclear Localization Sequence for Non-Viral Gene Delivery
por: Matschke, Johannes, et al.
Publicado: (2012)

Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20
por: Roman, Noelia, et al.
Publicado: (2013)

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A
por: Pawłowski, Rafał, et al.
Publicado: (2010)

407 Glucose activates STAT3, promoting XRCC1 expression and increased DNA repair after exogenous challenge
por: Gassman, Natalie R, et al.
Publicado: (2022)

Glucose Increases STAT3 Activation, Promoting Sustained XRCC1 Expression and Increasing DNA Repair
por: Wright, Griffin M., et al.
Publicado: (2022)

Activated STAT3 Is a Novel Regulator of the XRCC1 Promoter and Selectively Increases XRCC1 Protein Levels in Triple Negative Breast Cancer
por: Wright, Griffin, et al.
Publicado: (2021)

Characterization of the APLF FHA–XRCC1 phosphopeptide interaction and its structural and functional implications
por: Kim, Kyungmin, et al.
Publicado: (2017)

NLS-tagging: an alternative strategy to tag nuclear proteins
por: Giraud, Guillaume, et al.
Publicado: (2014)

DNA polymerase β contains a functional nuclear localization signal at its N-terminus
por: Kirby, Thomas W., et al.
Publicado: (2017)

Identification of a non-canonical nuclear localization signal (NLS) in BRCA1 that could mediate nuclear localization of splice variants lacking the classical NLS
por: Korlimarla, Aruna, et al.
Publicado: (2013)

Semiclassical focussing NLS
por: Kamvissis, S
Publicado: (2003)

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair
por: Hammel, Michal, et al.
Publicado: (2011)

Functional exchangeability of the nuclear localization signal (NLS) of capsid protein between PCV1 and PCV2 in vitro: Implications for the role of NLS in viral replication
por: Shuai, Jiangbing, et al.
Publicado: (2011)

Semiclassical NLS on the half line
por: Kamvissis, S
Publicado: (2002)

The structural basis for partitioning of the XRCC1/DNA ligase III-α BRCT-mediated dimer complexes
por: Cuneo, Matthew J., et al.
Publicado: (2011)

Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2
por: Lyst, Matthew J., et al.
Publicado: (2018)

On the question of analyticity of data for semiclassical NLS
por: Kamvissis, S
Publicado: (2001)

On the question of analyticity of data for semiclassical NLS
por: Kamvissis, S
Publicado: (2002)

Combining topic models with bipartite blockmodelling to uncover the multifaceted nature of social capital
por: Vlegels, Jef, et al.
Publicado: (2021)

Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK
por: Ali, Ammar A. E., et al.
Publicado: (2009)

DNA Ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair
por: Gao, Yankun, et al.
Publicado: (2011)

Tyrosine Phosphorylation in the C-Terminal Nuclear Localization and Retention Signal (C-NLS) of the EWS Protein
por: Leemann-Zakaryan, Ruzanna P., et al.
Publicado: (2011)

Evolutionary gradient of predicted nuclear localization signals (NLS)-bearing proteins in genomes of family Planctomycetaceae
por: Guo, Min, et al.
Publicado: (2017)

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains
por: Cherry, Amy L., et al.
Publicado: (2015)

SeqNLS: Nuclear Localization Signal Prediction Based on Frequent Pattern Mining and Linear Motif Scoring
por: Lin, Jhih-rong, et al.
Publicado: (2013)

Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry
por: Kachaner, David, et al.
Publicado: (2017)

Insights from the Molecular Modelling and Docking Analysis of AIF-NLS complex to infer Nuclear Translocation of the Protein
por: Srivaths, Akash, et al.
Publicado: (2018)

A variational problem related to semiclassical focusing NLS
por: Kamvissis, S
Publicado: (2002)

NLS-RARα is a novel transcriptional factor
por: Jiang, Kai-Ling, et al.
Publicado: (2017)

DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients
por: Santos, Raquel A., et al.
Publicado: (2010)

Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains
Publicado: (1995)

DNA Repair Genes and Chronic Myeloid Leukemia: ERCC2 (751), XRCC1 (399), XRCC4-Intron 3, XRCC4 (-1394) Gene Polymorphisms
por: Ozdilli, Kursat, et al.
Publicado: (2021)

The poset of bipartitions
por: Hetyei, Gábor, et al.
Publicado: (2011)

FUS-NLS/Transportin 1 Complex Structure Provides Insights into the Nuclear Targeting Mechanism of FUS and the Implications in ALS
por: Niu, Chunyan, et al.
Publicado: (2012)

In vivo characterization of chimeric PCV DNA clones containing heterogeneous capsid protein nuclear localization signals (NLS)
por: Shuai, Jiangbing, et al.
Publicado: (2013)

Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system
por: Han, Yuhong, et al.
Publicado: (2017)

DNA Repair Gene (XPD, XRCC4, and XRCC1) Polymorphisms in Patients with Endometrial Hyperplasia: A Pilot Study
por: Öztürk, Ebru, et al.
Publicado: (2018)

DNA repair gene XRCC1 polymorphisms and bladder cancer risk
por: Sak, Sei Chung, et al.
Publicado: (2007)

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer Risk
por: Kaur, Jagjeet, et al.
Publicado: (2020)

Human-derived NLS enhance the gene transfer efficiency of chitosan
por: Bitoque, Diogo B., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lfnal2uc7uu7p5c59ibo17n8br