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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

[Image: see text] The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1. However, the lack of intra-BET selectivity limits the scope of current i...

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Detalles Bibliográficos
Autores principales:	Zengerle, Michael, Chan, Kwok-Ho, Ciulli, Alessio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548256/ https://www.ncbi.nlm.nih.gov/pubmed/26035625 http://dx.doi.org/10.1021/acschembio.5b00216

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