Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials

Progesterone has been shown to have neuroprotective effects in multiple animal models of brain injury, whereas the efficacy and safety in patients with traumatic brain injury (TBI) remains contentious. Here, a total of seven randomized controlled trials (RCTs) with 2492 participants were included to...

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Autores principales: Lin, Chao, He, Hongquan, Li, Zheng, Liu, Yinglong, Chao, Honglu, Ji, Jing, Liu, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548259/
https://www.ncbi.nlm.nih.gov/pubmed/26304556
http://dx.doi.org/10.1038/srep13442
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author Lin, Chao
He, Hongquan
Li, Zheng
Liu, Yinglong
Chao, Honglu
Ji, Jing
Liu, Ning
author_facet Lin, Chao
He, Hongquan
Li, Zheng
Liu, Yinglong
Chao, Honglu
Ji, Jing
Liu, Ning
author_sort Lin, Chao
collection PubMed
description Progesterone has been shown to have neuroprotective effects in multiple animal models of brain injury, whereas the efficacy and safety in patients with traumatic brain injury (TBI) remains contentious. Here, a total of seven randomized controlled trials (RCTs) with 2492 participants were included to perform this meta-analysis. Compared with placebo, there was no significant decrease to be found in the rate of death or vegetative state for patients with acute TBI (RR = 0.88, 95%CI = 0.70, 1.09, p = 0.24). Furthermore, progesterone was not associated with good recovery in comparison with placebo (RR = 1.00, 95%CI = 0.88, 1.14, p = 0.95). Together, our study suggested that progesterone did not improve outcomes over placebo in the treatment of acute TBI.
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spelling pubmed-45482592015-08-26 Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials Lin, Chao He, Hongquan Li, Zheng Liu, Yinglong Chao, Honglu Ji, Jing Liu, Ning Sci Rep Article Progesterone has been shown to have neuroprotective effects in multiple animal models of brain injury, whereas the efficacy and safety in patients with traumatic brain injury (TBI) remains contentious. Here, a total of seven randomized controlled trials (RCTs) with 2492 participants were included to perform this meta-analysis. Compared with placebo, there was no significant decrease to be found in the rate of death or vegetative state for patients with acute TBI (RR = 0.88, 95%CI = 0.70, 1.09, p = 0.24). Furthermore, progesterone was not associated with good recovery in comparison with placebo (RR = 1.00, 95%CI = 0.88, 1.14, p = 0.95). Together, our study suggested that progesterone did not improve outcomes over placebo in the treatment of acute TBI. Nature Publishing Group 2015-08-25 /pmc/articles/PMC4548259/ /pubmed/26304556 http://dx.doi.org/10.1038/srep13442 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lin, Chao
He, Hongquan
Li, Zheng
Liu, Yinglong
Chao, Honglu
Ji, Jing
Liu, Ning
Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials
title Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials
title_full Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials
title_fullStr Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials
title_full_unstemmed Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials
title_short Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials
title_sort efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548259/
https://www.ncbi.nlm.nih.gov/pubmed/26304556
http://dx.doi.org/10.1038/srep13442
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