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Procalcitonin levels in salmonella infection

AIM: Procalcitonin (PCT) as a diagnostic marker for bacteremia and sepsis has been extensively studied. We aimed to study PCT levels in Salmonella infections whether they would serve as marker for early diagnosis in endemic areas to start empiric treatment while awaiting blood culture report. MATERI...

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Detalles Bibliográficos
Autores principales: Mishra, Vikas, Sorabjee, Jehangir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548417/
https://www.ncbi.nlm.nih.gov/pubmed/26321807
http://dx.doi.org/10.4103/0972-5229.162466
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author Mishra, Vikas
Sorabjee, Jehangir
author_facet Mishra, Vikas
Sorabjee, Jehangir
author_sort Mishra, Vikas
collection PubMed
description AIM: Procalcitonin (PCT) as a diagnostic marker for bacteremia and sepsis has been extensively studied. We aimed to study PCT levels in Salmonella infections whether they would serve as marker for early diagnosis in endemic areas to start empiric treatment while awaiting blood culture report. MATERIALS AND METHODS: BACTEC blood culture was used to isolate Salmonella in suspected enteric fever patients. Serum PCT levels were estimated before starting treatment. RESULTS: In 60 proven enteric fever patients, median value of serum PCT levels was 0.22 ng/ml, values ranging between 0.05 and 4 ng/ml. 95% of patients had near normal or mild increase (<0.5 ng/ml), only 5% of patients showed elevated levels. Notably, high PCT levels were found only in severe sepsis. CONCLUSION: PCT levels in Salmonella infections are near normal or minimally increased which differentiates it from other systemic Gram-negative infections. PCT cannot be used as a specific diagnostic marker of typhoid.
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spelling pubmed-45484172015-08-28 Procalcitonin levels in salmonella infection Mishra, Vikas Sorabjee, Jehangir Indian J Crit Care Med Brief Communication AIM: Procalcitonin (PCT) as a diagnostic marker for bacteremia and sepsis has been extensively studied. We aimed to study PCT levels in Salmonella infections whether they would serve as marker for early diagnosis in endemic areas to start empiric treatment while awaiting blood culture report. MATERIALS AND METHODS: BACTEC blood culture was used to isolate Salmonella in suspected enteric fever patients. Serum PCT levels were estimated before starting treatment. RESULTS: In 60 proven enteric fever patients, median value of serum PCT levels was 0.22 ng/ml, values ranging between 0.05 and 4 ng/ml. 95% of patients had near normal or mild increase (<0.5 ng/ml), only 5% of patients showed elevated levels. Notably, high PCT levels were found only in severe sepsis. CONCLUSION: PCT levels in Salmonella infections are near normal or minimally increased which differentiates it from other systemic Gram-negative infections. PCT cannot be used as a specific diagnostic marker of typhoid. Medknow Publications & Media Pvt Ltd 2015-08 /pmc/articles/PMC4548417/ /pubmed/26321807 http://dx.doi.org/10.4103/0972-5229.162466 Text en Copyright: © Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Mishra, Vikas
Sorabjee, Jehangir
Procalcitonin levels in salmonella infection
title Procalcitonin levels in salmonella infection
title_full Procalcitonin levels in salmonella infection
title_fullStr Procalcitonin levels in salmonella infection
title_full_unstemmed Procalcitonin levels in salmonella infection
title_short Procalcitonin levels in salmonella infection
title_sort procalcitonin levels in salmonella infection
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548417/
https://www.ncbi.nlm.nih.gov/pubmed/26321807
http://dx.doi.org/10.4103/0972-5229.162466
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