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Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population
BACKGROUND: Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548694/ https://www.ncbi.nlm.nih.gov/pubmed/26302849 http://dx.doi.org/10.1186/s12876-015-0336-9 |
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author | Su, Qinghua Wang, Yuan Zhao, Jun Ma, Cangjian Wu, Tao Jin, Tianbo Xu, Jinkai |
author_facet | Su, Qinghua Wang, Yuan Zhao, Jun Ma, Cangjian Wu, Tao Jin, Tianbo Xu, Jinkai |
author_sort | Su, Qinghua |
collection | PubMed |
description | BACKGROUND: Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal cancers in the Chinese Han population. METHODS: We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ2 test and genetic model analysis. RESULTS: The genotype “A/T” of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95 % confidence interval (CI) = 0.68–0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95 % CI = 0.66–0.98; p = 0.032). The genotype “A/G” of rs1665650 in HSPA12A gene was associated with a decreased risk of gastric cancer in overdominant model analysis (OR = 0.77; 95 % CI = 0.60–0.99; p = 0.038). CONCLUSIONS: Our results provide evidence that variants of PRLHR gene are a protective factor in colorectal cancer and variants of HSPA12A gene are a protective factor in gastric cancer in the Chinese Han population. |
format | Online Article Text |
id | pubmed-4548694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45486942015-08-26 Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population Su, Qinghua Wang, Yuan Zhao, Jun Ma, Cangjian Wu, Tao Jin, Tianbo Xu, Jinkai BMC Gastroenterol Research Article BACKGROUND: Gastric and colorectal cancers have a major impact on public health, and are the most common malignant tumors in China. The aim of this research was to study whether polymorphisms of CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3 and C11orf93-C11orf92 genes are associated with the risk of gastric and colorectal cancers in the Chinese Han population. METHODS: We genotyped seven single nucleotide polymorphisms (SNPs) from seven genes. We selected 588 patients with gastric cancer and 449 with colorectal cancer, along with 703 healthy controls. All these SNPs were evaluated using the χ2 test and genetic model analysis. RESULTS: The genotype “A/T” of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95 % confidence interval (CI) = 0.68–0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95 % CI = 0.66–0.98; p = 0.032). The genotype “A/G” of rs1665650 in HSPA12A gene was associated with a decreased risk of gastric cancer in overdominant model analysis (OR = 0.77; 95 % CI = 0.60–0.99; p = 0.038). CONCLUSIONS: Our results provide evidence that variants of PRLHR gene are a protective factor in colorectal cancer and variants of HSPA12A gene are a protective factor in gastric cancer in the Chinese Han population. BioMed Central 2015-08-25 /pmc/articles/PMC4548694/ /pubmed/26302849 http://dx.doi.org/10.1186/s12876-015-0336-9 Text en © Su et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Su, Qinghua Wang, Yuan Zhao, Jun Ma, Cangjian Wu, Tao Jin, Tianbo Xu, Jinkai Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population |
title | Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population |
title_full | Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population |
title_fullStr | Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population |
title_full_unstemmed | Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population |
title_short | Polymorphisms of PRLHR and HSPA12A and risk of gastric and colorectal cancer in the Chinese Han population |
title_sort | polymorphisms of prlhr and hspa12a and risk of gastric and colorectal cancer in the chinese han population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548694/ https://www.ncbi.nlm.nih.gov/pubmed/26302849 http://dx.doi.org/10.1186/s12876-015-0336-9 |
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