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Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rg(null) RIP-DTR mice engrafted with human islets

OBJECTIVE: Glucagon-like peptide-1 induces glucose-dependent insulin secretion and, in rodents, increases proliferation and survival of pancreatic beta cells. To investigate the effects on human beta cells, we used immunodeficient mice transplanted with human islets. The goal was to determine whethe...

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Detalles Bibliográficos
Autores principales:	Yang, Chaoxing, Loehn, Matthias, Jurczyk, Agata, Przewozniak, Natalia, Leehy, Linda, Herrera, Pedro L, Shultz, Leonard D, Greiner, Dale L, Harlan, David M, Bortell, Rita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548726/ https://www.ncbi.nlm.nih.gov/pubmed/26316789 http://dx.doi.org/10.2147/DMSO.S87253

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