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Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma

BACKGROUND: Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. There are at present no reliable prognostic biomark...

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Autores principales: Rikardsen, Oddveig G., Magnussen, Synnøve N., Svineng, Gunbjørg, Hadler-Olsen, Elin, Uhlin-Hansen, Lars, Steigen, Sonja E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548848/
https://www.ncbi.nlm.nih.gov/pubmed/26306491
http://dx.doi.org/10.1186/s12903-015-0084-9
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author Rikardsen, Oddveig G.
Magnussen, Synnøve N.
Svineng, Gunbjørg
Hadler-Olsen, Elin
Uhlin-Hansen, Lars
Steigen, Sonja E.
author_facet Rikardsen, Oddveig G.
Magnussen, Synnøve N.
Svineng, Gunbjørg
Hadler-Olsen, Elin
Uhlin-Hansen, Lars
Steigen, Sonja E.
author_sort Rikardsen, Oddveig G.
collection PubMed
description BACKGROUND: Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. There are at present no reliable prognostic biomarkers for oral cancers. Thus, to optimize treatment for the individual patient, there is a need for biomarkers that can predict tumor behavior. METHOD: In the present study the potential prognostic value of plectin was evaluated by a tissue microarray (TMA) based immunohistochemical analysis of primary tumor tissue obtained from a North Norwegian cohort of 115 patients diagnosed with OSCC. The expression of plectin was compared with clinicopathological variables and 5 year survival. RESULTS: The statistical analysis revealed that low expression of plectin in the tumor cells predicted a favorable outcome for patients with non-metastatic disease (p = 0.008). Furthermore, the expression of plectin was found to correlate (p = 0.01) with the expression of uPAR, which we have previously found to be a potential prognostic marker for T1N0 tumors. CONCLUSIONS: Our results indicate that low expression of plectin predicts a favorable outcome for patients with non-metastatic OSCC and the expression level of plectin may therefore be used in the treatment stratification for patients with early stage disease.
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spelling pubmed-45488482015-08-26 Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma Rikardsen, Oddveig G. Magnussen, Synnøve N. Svineng, Gunbjørg Hadler-Olsen, Elin Uhlin-Hansen, Lars Steigen, Sonja E. BMC Oral Health Research Article BACKGROUND: Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. There are at present no reliable prognostic biomarkers for oral cancers. Thus, to optimize treatment for the individual patient, there is a need for biomarkers that can predict tumor behavior. METHOD: In the present study the potential prognostic value of plectin was evaluated by a tissue microarray (TMA) based immunohistochemical analysis of primary tumor tissue obtained from a North Norwegian cohort of 115 patients diagnosed with OSCC. The expression of plectin was compared with clinicopathological variables and 5 year survival. RESULTS: The statistical analysis revealed that low expression of plectin in the tumor cells predicted a favorable outcome for patients with non-metastatic disease (p = 0.008). Furthermore, the expression of plectin was found to correlate (p = 0.01) with the expression of uPAR, which we have previously found to be a potential prognostic marker for T1N0 tumors. CONCLUSIONS: Our results indicate that low expression of plectin predicts a favorable outcome for patients with non-metastatic OSCC and the expression level of plectin may therefore be used in the treatment stratification for patients with early stage disease. BioMed Central 2015-08-26 /pmc/articles/PMC4548848/ /pubmed/26306491 http://dx.doi.org/10.1186/s12903-015-0084-9 Text en © Rikardsen et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Rikardsen, Oddveig G.
Magnussen, Synnøve N.
Svineng, Gunbjørg
Hadler-Olsen, Elin
Uhlin-Hansen, Lars
Steigen, Sonja E.
Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
title Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
title_full Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
title_fullStr Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
title_full_unstemmed Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
title_short Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
title_sort plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548848/
https://www.ncbi.nlm.nih.gov/pubmed/26306491
http://dx.doi.org/10.1186/s12903-015-0084-9
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