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The successful search for genetic loci associated with depression
Major depressive disorder is among the leading causes of disease burden and disability, as well as a major public health concern worldwide. Despite its substantial heritability, no robustly replicated genetic risk loci had been found until recently. Now, a new study has identified, and replicated, t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548917/ https://www.ncbi.nlm.nih.gov/pubmed/26302953 http://dx.doi.org/10.1186/s13073-015-0217-4 |
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author | Rivera, Margarita McGuffin, Peter |
author_facet | Rivera, Margarita McGuffin, Peter |
author_sort | Rivera, Margarita |
collection | PubMed |
description | Major depressive disorder is among the leading causes of disease burden and disability, as well as a major public health concern worldwide. Despite its substantial heritability, no robustly replicated genetic risk loci had been found until recently. Now, a new study has identified, and replicated, two variants associated with an increased risk for this disorder. The success of this study appears to lie in the use of low-coverage sequencing, instead of microarrays, and in minimizing phenotypic and genetic heterogeneity. |
format | Online Article Text |
id | pubmed-4548917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45489172015-08-26 The successful search for genetic loci associated with depression Rivera, Margarita McGuffin, Peter Genome Med Research Highlight Major depressive disorder is among the leading causes of disease burden and disability, as well as a major public health concern worldwide. Despite its substantial heritability, no robustly replicated genetic risk loci had been found until recently. Now, a new study has identified, and replicated, two variants associated with an increased risk for this disorder. The success of this study appears to lie in the use of low-coverage sequencing, instead of microarrays, and in minimizing phenotypic and genetic heterogeneity. BioMed Central 2015-08-25 /pmc/articles/PMC4548917/ /pubmed/26302953 http://dx.doi.org/10.1186/s13073-015-0217-4 Text en © Rivera and McGuffin. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Highlight Rivera, Margarita McGuffin, Peter The successful search for genetic loci associated with depression |
title | The successful search for genetic loci associated with depression |
title_full | The successful search for genetic loci associated with depression |
title_fullStr | The successful search for genetic loci associated with depression |
title_full_unstemmed | The successful search for genetic loci associated with depression |
title_short | The successful search for genetic loci associated with depression |
title_sort | successful search for genetic loci associated with depression |
topic | Research Highlight |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548917/ https://www.ncbi.nlm.nih.gov/pubmed/26302953 http://dx.doi.org/10.1186/s13073-015-0217-4 |
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