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Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease

BACKGROUND: Patients with essential tremor (ET) who develop Parkinson’s disease (PD) (i.e., ET→PD) may differ with respect to motor features (MFs) and non-motor features (NMFs) from patients with isolated ET. Few studies have assessed this issue. METHODS: In this retrospective chart review, we analy...

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Autores principales: Ghika, Apostolia, Kyrozis, Andreas, Potagas, Constantinos, Louis, Elan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548968/
https://www.ncbi.nlm.nih.gov/pubmed/26336614
http://dx.doi.org/10.7916/D83777WK
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author Ghika, Apostolia
Kyrozis, Andreas
Potagas, Constantinos
Louis, Elan D.
author_facet Ghika, Apostolia
Kyrozis, Andreas
Potagas, Constantinos
Louis, Elan D.
author_sort Ghika, Apostolia
collection PubMed
description BACKGROUND: Patients with essential tremor (ET) who develop Parkinson’s disease (PD) (i.e., ET→PD) may differ with respect to motor features (MFs) and non-motor features (NMFs) from patients with isolated ET. Few studies have assessed this issue. METHODS: In this retrospective chart review, we analyzed data on MFs and NMFs of 175 patients, including 54 ET→PD and 121 ET, actively followed in the Athens University 1st Neurology Department. RESULTS: Significantly more ET→PD than ET patients reported asymmetric tremor at ET onset (68.5% vs. 14.9%, p<0.001). Significantly more ET than ET→PD patients had head tremor (43.5% vs. 13.2%, p<0.001) and cerebellar signs (41.3% vs. 9.3%, p<0.001). More ET than ET→PD patients reported hearing impairment (65.3% vs. 28.3%, p<0.001) and restless legs syndrome (34.8% vs. 3.7%, p<0.001). Conversely, a larger proportion of ET→PD than ET patients reported rapid eye movement behavior disorder (51.9% vs. 10.0%, p<0.001), constipation (67.9% vs. 36.4%, p<0.001), and olfactory dysfunction (83.3% vs. 36.4%, p<0.001). DISCUSSION: The subset of ET→PD patients may have distinct MFs and NMFs that should be assessed further for the possible predictive value for the emergence of PD.
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spelling pubmed-45489682015-09-02 Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease Ghika, Apostolia Kyrozis, Andreas Potagas, Constantinos Louis, Elan D. Tremor Other Hyperkinet Mov (N Y) Brief Reports BACKGROUND: Patients with essential tremor (ET) who develop Parkinson’s disease (PD) (i.e., ET→PD) may differ with respect to motor features (MFs) and non-motor features (NMFs) from patients with isolated ET. Few studies have assessed this issue. METHODS: In this retrospective chart review, we analyzed data on MFs and NMFs of 175 patients, including 54 ET→PD and 121 ET, actively followed in the Athens University 1st Neurology Department. RESULTS: Significantly more ET→PD than ET patients reported asymmetric tremor at ET onset (68.5% vs. 14.9%, p<0.001). Significantly more ET than ET→PD patients had head tremor (43.5% vs. 13.2%, p<0.001) and cerebellar signs (41.3% vs. 9.3%, p<0.001). More ET than ET→PD patients reported hearing impairment (65.3% vs. 28.3%, p<0.001) and restless legs syndrome (34.8% vs. 3.7%, p<0.001). Conversely, a larger proportion of ET→PD than ET patients reported rapid eye movement behavior disorder (51.9% vs. 10.0%, p<0.001), constipation (67.9% vs. 36.4%, p<0.001), and olfactory dysfunction (83.3% vs. 36.4%, p<0.001). DISCUSSION: The subset of ET→PD patients may have distinct MFs and NMFs that should be assessed further for the possible predictive value for the emergence of PD. Columbia University Libraries/Information Services 2015-08-14 /pmc/articles/PMC4548968/ /pubmed/26336614 http://dx.doi.org/10.7916/D83777WK Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommerical–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
spellingShingle Brief Reports
Ghika, Apostolia
Kyrozis, Andreas
Potagas, Constantinos
Louis, Elan D.
Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease
title Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease
title_full Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease
title_fullStr Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease
title_full_unstemmed Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease
title_short Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease
title_sort motor and non-motor features: differences between patients with isolated essential tremor and patients with both essential tremor and parkinson’s disease
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548968/
https://www.ncbi.nlm.nih.gov/pubmed/26336614
http://dx.doi.org/10.7916/D83777WK
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