Memantine-induced Myoclonus in a Patient with Alzheimer Disease

BACKGROUND: Myoclonus can be a clinical manifestation of numerous neurodegenerative disorders and an adverse drug reaction to medications used in their treatment. CASE REPORT: Herein, we report memantine-induced myoclonus in a patient with Alzheimer disease. The myoclonus seen in our patient was gen...

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Detalles Bibliográficos
Autores principales: Murgai, Aditya A., LeDoux, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548970/
https://www.ncbi.nlm.nih.gov/pubmed/26317045
http://dx.doi.org/10.7916/D8ZG6RD9
Descripción
Sumario:BACKGROUND: Myoclonus can be a clinical manifestation of numerous neurodegenerative disorders and an adverse drug reaction to medications used in their treatment. CASE REPORT: Herein, we report memantine-induced myoclonus in a patient with Alzheimer disease. The myoclonus seen in our patient was generalized (proximal limbs and trunk), present at rest and with action, and stimulus sensitive. A structured evaluation with the Unified Myoclonus Rating Scale showed that the myoclonus had no significant effect on functional capacity. After discontinuation of memantine, myoclonus slowly resolved over the course of several weeks. DISCUSSION: Memantine may cause myoclonus in susceptible individuals.

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