Memantine-induced Myoclonus in a Patient with Alzheimer Disease

BACKGROUND: Myoclonus can be a clinical manifestation of numerous neurodegenerative disorders and an adverse drug reaction to medications used in their treatment. CASE REPORT: Herein, we report memantine-induced myoclonus in a patient with Alzheimer disease. The myoclonus seen in our patient was gen...

Descripción completa

Detalles Bibliográficos
Autores principales: Murgai, Aditya A., LeDoux, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548970/
https://www.ncbi.nlm.nih.gov/pubmed/26317045
http://dx.doi.org/10.7916/D8ZG6RD9
_version_ 1782387247372304384
author Murgai, Aditya A.
LeDoux, Mark S.
author_facet Murgai, Aditya A.
LeDoux, Mark S.
author_sort Murgai, Aditya A.
collection PubMed
description BACKGROUND: Myoclonus can be a clinical manifestation of numerous neurodegenerative disorders and an adverse drug reaction to medications used in their treatment. CASE REPORT: Herein, we report memantine-induced myoclonus in a patient with Alzheimer disease. The myoclonus seen in our patient was generalized (proximal limbs and trunk), present at rest and with action, and stimulus sensitive. A structured evaluation with the Unified Myoclonus Rating Scale showed that the myoclonus had no significant effect on functional capacity. After discontinuation of memantine, myoclonus slowly resolved over the course of several weeks. DISCUSSION: Memantine may cause myoclonus in susceptible individuals.
format Online
Article
Text
id pubmed-4548970
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Columbia University Libraries/Information Services
record_format MEDLINE/PubMed
spelling pubmed-45489702015-08-27 Memantine-induced Myoclonus in a Patient with Alzheimer Disease Murgai, Aditya A. LeDoux, Mark S. Tremor Other Hyperkinet Mov (N Y) Case Reports BACKGROUND: Myoclonus can be a clinical manifestation of numerous neurodegenerative disorders and an adverse drug reaction to medications used in their treatment. CASE REPORT: Herein, we report memantine-induced myoclonus in a patient with Alzheimer disease. The myoclonus seen in our patient was generalized (proximal limbs and trunk), present at rest and with action, and stimulus sensitive. A structured evaluation with the Unified Myoclonus Rating Scale showed that the myoclonus had no significant effect on functional capacity. After discontinuation of memantine, myoclonus slowly resolved over the course of several weeks. DISCUSSION: Memantine may cause myoclonus in susceptible individuals. Columbia University Libraries/Information Services 2015-08-14 /pmc/articles/PMC4548970/ /pubmed/26317045 http://dx.doi.org/10.7916/D8ZG6RD9 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommerical–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
spellingShingle Case Reports
Murgai, Aditya A.
LeDoux, Mark S.
Memantine-induced Myoclonus in a Patient with Alzheimer Disease
title Memantine-induced Myoclonus in a Patient with Alzheimer Disease
title_full Memantine-induced Myoclonus in a Patient with Alzheimer Disease
title_fullStr Memantine-induced Myoclonus in a Patient with Alzheimer Disease
title_full_unstemmed Memantine-induced Myoclonus in a Patient with Alzheimer Disease
title_short Memantine-induced Myoclonus in a Patient with Alzheimer Disease
title_sort memantine-induced myoclonus in a patient with alzheimer disease
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548970/
https://www.ncbi.nlm.nih.gov/pubmed/26317045
http://dx.doi.org/10.7916/D8ZG6RD9
work_keys_str_mv AT murgaiadityaa memantineinducedmyoclonusinapatientwithalzheimerdisease
AT ledouxmarks memantineinducedmyoclonusinapatientwithalzheimerdisease

Ejemplares similares