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Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia characterized by syncope and sudden death occurring during exercise or acute emotion. CPVT is caused by abnormal intracellular Ca(2+) handling resulting from mutations in the RyR2 or CASQ2 genes. Because CASQ2 an...

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Detalles Bibliográficos
Autores principales:	Novak, Atara, Barad, Lili, Lorber, Avraham, Gherghiceanu, Mihaela, Reiter, Irina, Eisen, Binyamin, Eldor, Liron, Itskovitz-Eldor, Joseph, Eldar, Michael, Arad, Michael, Binah, Ofer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549051/ https://www.ncbi.nlm.nih.gov/pubmed/26153920 http://dx.doi.org/10.1111/jcmm.12581

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