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Chromatin states and nuclear organization in development — a view from the nuclear lamina

The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina–heterochromatin interactions is helping...

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Detalles Bibliográficos
Autores principales: Mattout, Anna, Cabianca, Daphne S., Gasser, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549078/
https://www.ncbi.nlm.nih.gov/pubmed/26303512
http://dx.doi.org/10.1186/s13059-015-0747-5
Descripción
Sumario:The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina–heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.