Chromatin states and nuclear organization in development — a view from the nuclear lamina

The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina–heterochromatin interactions is helping...

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Detalles Bibliográficos
Autores principales: Mattout, Anna, Cabianca, Daphne S., Gasser, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549078/
https://www.ncbi.nlm.nih.gov/pubmed/26303512
http://dx.doi.org/10.1186/s13059-015-0747-5
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author Mattout, Anna
Cabianca, Daphne S.
Gasser, Susan M.
author_facet Mattout, Anna
Cabianca, Daphne S.
Gasser, Susan M.
author_sort Mattout, Anna
collection PubMed
description The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina–heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.
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spelling pubmed-45490782015-08-26 Chromatin states and nuclear organization in development — a view from the nuclear lamina Mattout, Anna Cabianca, Daphne S. Gasser, Susan M. Genome Biol Review The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina–heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization. BioMed Central 2015-08-25 2015 /pmc/articles/PMC4549078/ /pubmed/26303512 http://dx.doi.org/10.1186/s13059-015-0747-5 Text en © Mattout et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Mattout, Anna
Cabianca, Daphne S.
Gasser, Susan M.
Chromatin states and nuclear organization in development — a view from the nuclear lamina
title Chromatin states and nuclear organization in development — a view from the nuclear lamina
title_full Chromatin states and nuclear organization in development — a view from the nuclear lamina
title_fullStr Chromatin states and nuclear organization in development — a view from the nuclear lamina
title_full_unstemmed Chromatin states and nuclear organization in development — a view from the nuclear lamina
title_short Chromatin states and nuclear organization in development — a view from the nuclear lamina
title_sort chromatin states and nuclear organization in development — a view from the nuclear lamina
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549078/
https://www.ncbi.nlm.nih.gov/pubmed/26303512
http://dx.doi.org/10.1186/s13059-015-0747-5
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