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Acidosis Is a key regulator of osteoblast ecto‐nucleotidase pyrophosphatase/phosphodiesterase 1 (NPP1) expression and activity

Previous work has shown that acidosis prevents bone nodule formation by osteoblasts in vitro by inhibiting mineralisation of the collagenous matrix. The ratio of phosphate (P(i)) to pyrophosphate (PP(i)) in the bone microenvironment is a fundamental regulator of bone mineralisation. Both P(i) and PP...

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Detalles Bibliográficos
Autores principales:	Orriss, Isabel R., Key, Michelle L., Hajjawi, Mark O.R., Millán, José L., Arnett, Timothy R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549203/ https://www.ncbi.nlm.nih.gov/pubmed/26033523 http://dx.doi.org/10.1002/jcp.25041

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