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Corollary Discharge Failure in an Oculomotor Task Is Related to Delusional Ideation in Healthy Individuals

Predicting the sensory consequences of saccadic eye movements likely plays a crucial role in planning sequences of saccades and in maintaining visual stability despite saccade-caused retinal displacements. Deficits in predictive activity, such as that afforded by a corollary discharge signal, have b...

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Autores principales: Malassis, Raphaëlle, Del Cul, Antoine, Collins, Thérèse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549245/
https://www.ncbi.nlm.nih.gov/pubmed/26305115
http://dx.doi.org/10.1371/journal.pone.0134483
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author Malassis, Raphaëlle
Del Cul, Antoine
Collins, Thérèse
author_facet Malassis, Raphaëlle
Del Cul, Antoine
Collins, Thérèse
author_sort Malassis, Raphaëlle
collection PubMed
description Predicting the sensory consequences of saccadic eye movements likely plays a crucial role in planning sequences of saccades and in maintaining visual stability despite saccade-caused retinal displacements. Deficits in predictive activity, such as that afforded by a corollary discharge signal, have been reported in patients with schizophrenia, and may lead to the emergence of positive symptoms, in particular delusions of control and auditory hallucinations. We examined whether a measure of delusional thinking in the general, non-clinical population correlated with measures of predictive activity in two oculomotor tasks. The double-step task measured predictive activity in motor control, and the in-flight displacement task measured predictive activity in trans-saccadic visual perception. Forty-one healthy adults performed both tasks and completed a questionnaire to assess delusional thinking. The quantitative measure of predictive activity we obtained correlated with the tendency towards delusional ideation, but only for the motor task, and not the perceptual task: Individuals with higher levels of delusional thinking showed less self-movement information use in the motor task. Variation of the degree of self-generated movement knowledge as a function of the prevalence of delusional ideation in the normal population strongly supports the idea that corollary discharge deficits measured in schizophrenic patients in previous researches are not due to neuroleptic medication. We also propose that this difference in results between the perceptual and the motor tasks may point to a dissociation between corollary discharge for perception and corollary discharge for action.
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spelling pubmed-45492452015-09-01 Corollary Discharge Failure in an Oculomotor Task Is Related to Delusional Ideation in Healthy Individuals Malassis, Raphaëlle Del Cul, Antoine Collins, Thérèse PLoS One Research Article Predicting the sensory consequences of saccadic eye movements likely plays a crucial role in planning sequences of saccades and in maintaining visual stability despite saccade-caused retinal displacements. Deficits in predictive activity, such as that afforded by a corollary discharge signal, have been reported in patients with schizophrenia, and may lead to the emergence of positive symptoms, in particular delusions of control and auditory hallucinations. We examined whether a measure of delusional thinking in the general, non-clinical population correlated with measures of predictive activity in two oculomotor tasks. The double-step task measured predictive activity in motor control, and the in-flight displacement task measured predictive activity in trans-saccadic visual perception. Forty-one healthy adults performed both tasks and completed a questionnaire to assess delusional thinking. The quantitative measure of predictive activity we obtained correlated with the tendency towards delusional ideation, but only for the motor task, and not the perceptual task: Individuals with higher levels of delusional thinking showed less self-movement information use in the motor task. Variation of the degree of self-generated movement knowledge as a function of the prevalence of delusional ideation in the normal population strongly supports the idea that corollary discharge deficits measured in schizophrenic patients in previous researches are not due to neuroleptic medication. We also propose that this difference in results between the perceptual and the motor tasks may point to a dissociation between corollary discharge for perception and corollary discharge for action. Public Library of Science 2015-08-25 /pmc/articles/PMC4549245/ /pubmed/26305115 http://dx.doi.org/10.1371/journal.pone.0134483 Text en © 2015 Malassis et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Malassis, Raphaëlle
Del Cul, Antoine
Collins, Thérèse
Corollary Discharge Failure in an Oculomotor Task Is Related to Delusional Ideation in Healthy Individuals
title Corollary Discharge Failure in an Oculomotor Task Is Related to Delusional Ideation in Healthy Individuals
title_full Corollary Discharge Failure in an Oculomotor Task Is Related to Delusional Ideation in Healthy Individuals
title_fullStr Corollary Discharge Failure in an Oculomotor Task Is Related to Delusional Ideation in Healthy Individuals
title_full_unstemmed Corollary Discharge Failure in an Oculomotor Task Is Related to Delusional Ideation in Healthy Individuals
title_short Corollary Discharge Failure in an Oculomotor Task Is Related to Delusional Ideation in Healthy Individuals
title_sort corollary discharge failure in an oculomotor task is related to delusional ideation in healthy individuals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549245/
https://www.ncbi.nlm.nih.gov/pubmed/26305115
http://dx.doi.org/10.1371/journal.pone.0134483
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