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Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation

Poly (ADP-ribose) polymerase-1 (PARP1) is a nuclear enzyme involved in DNA repair, chromatin remodeling and gene expression. PARP1 interactions with chromatin architectural multi-protein complexes (i.e. nucleosomes) alter chromatin structure resulting in changes in gene expression. Chromatin structu...

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Detalles Bibliográficos
Autores principales:	Nalabothula, Narasimharao, Al-jumaily, Taha, Eteleeb, Abdallah M., Flight, Robert M., Xiaorong, Shao, Moseley, Hunter, Rouchka, Eric C., Fondufe-Mittendorf, Yvonne N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549251/ https://www.ncbi.nlm.nih.gov/pubmed/26305327 http://dx.doi.org/10.1371/journal.pone.0135410

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