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SERPINE2 Inhibits IL-1α-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-κB/AP-1 Pathways

OBJECTIVES: Osteoarthritis (OA) is a chronic joint disease, characterized by a progressive loss of articular cartilage. During OA, proinflammatory cytokines, such as interleukin IL-1, induce the expression of matrix metalloproteinases (MMPs) in chondrocytes, contributing thus to the extracellular ma...

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Detalles Bibliográficos
Autores principales:	Santoro, Anna, Conde, Javier, Scotece, Morena, Abella, Vanessa, Lois, Ana, Lopez, Veronica, Pino, Jesus, Gomez, Rodolfo, Gomez-Reino, Juan J., Gualillo, Oreste
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549255/ https://www.ncbi.nlm.nih.gov/pubmed/26305372 http://dx.doi.org/10.1371/journal.pone.0135979

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