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Decreased 11β-Hydroxysteroid Dehydrogenase 1 Level and Activity in Murine Pancreatic Islets Caused by Insulin-Like Growth Factor I Overexpression

We have reported a high expression of IGF-I in pancreatic islet β-cells of transgenic mice under the metallothionein promoter. cDNA microarray analysis of the islets revealed that the expression of 82 genes was significantly altered compared to wild-type mice. Of these, 11β-hydroxysteroid dehydrogen...

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Detalles Bibliográficos
Autores principales:	Chowdhury, Subrata, Grimm, Larson, Gong, Ying Jia Kate, Wang, Beixi, Li, Bing, Srikant, Coimbatore B., Gao, Zu-hua, Liu, Jun-Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549276/ https://www.ncbi.nlm.nih.gov/pubmed/26305481 http://dx.doi.org/10.1371/journal.pone.0136656

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