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Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis

Visceral leishmaniasis (VL) in patients with HIV co-infection presents a significant therapeutic challenge due to the lessened chance of achieving long-term cure. We report a case of VL in a 60-year-old man with HIV infection who became refractory to anti-leishmania treatment due to multi-drug resis...

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Detalles Bibliográficos
Autores principales: Gow, Nicholas J., Davidson, Robert N., Ticehurst, Rob, Burns, Andrew, Thomas, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549335/
https://www.ncbi.nlm.nih.gov/pubmed/26305562
http://dx.doi.org/10.1371/journal.pntd.0003983
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author Gow, Nicholas J.
Davidson, Robert N.
Ticehurst, Rob
Burns, Andrew
Thomas, Mark G.
author_facet Gow, Nicholas J.
Davidson, Robert N.
Ticehurst, Rob
Burns, Andrew
Thomas, Mark G.
author_sort Gow, Nicholas J.
collection PubMed
description Visceral leishmaniasis (VL) in patients with HIV co-infection presents a significant therapeutic challenge due to the lessened chance of achieving long-term cure. We report a case of VL in a 60-year-old man with HIV infection who became refractory to anti-leishmania treatment due to multi-drug resistance. In the face of a worsening clinical situation, and with no other options available, he was treated with an experimental regimen of liposomal daunorubicin, which has previously been shown to have in vitro activity against Leishmania donovani and to be effective treatment of VL in animal studies. To our knowledge, he was the first patient with VL and HIV co-infection to have this treatment evaluated. We report on the lack of response to this treatment and possible causes for its failure.
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spelling pubmed-45493352015-09-01 Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis Gow, Nicholas J. Davidson, Robert N. Ticehurst, Rob Burns, Andrew Thomas, Mark G. PLoS Negl Trop Dis Research Article Visceral leishmaniasis (VL) in patients with HIV co-infection presents a significant therapeutic challenge due to the lessened chance of achieving long-term cure. We report a case of VL in a 60-year-old man with HIV infection who became refractory to anti-leishmania treatment due to multi-drug resistance. In the face of a worsening clinical situation, and with no other options available, he was treated with an experimental regimen of liposomal daunorubicin, which has previously been shown to have in vitro activity against Leishmania donovani and to be effective treatment of VL in animal studies. To our knowledge, he was the first patient with VL and HIV co-infection to have this treatment evaluated. We report on the lack of response to this treatment and possible causes for its failure. Public Library of Science 2015-08-25 /pmc/articles/PMC4549335/ /pubmed/26305562 http://dx.doi.org/10.1371/journal.pntd.0003983 Text en © 2015 Gow et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Gow, Nicholas J.
Davidson, Robert N.
Ticehurst, Rob
Burns, Andrew
Thomas, Mark G.
Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis
title Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis
title_full Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis
title_fullStr Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis
title_full_unstemmed Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis
title_short Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis
title_sort case report: no response to liposomal daunorubicin in a patient with drug-resistant hiv-associated visceral leishmaniasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549335/
https://www.ncbi.nlm.nih.gov/pubmed/26305562
http://dx.doi.org/10.1371/journal.pntd.0003983
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