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Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child

Various autoantibodies have been reported to be detected during the progression of infectious mononucleosis. We observed a case of infectious mononucleosis due to Epstein–Barr virus primary infection for 2 months, and noticed the transiently increased titer of thyrotropin receptor autoantibodies det...

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Autores principales: Nagata, Keiko, Okuno, Keisuke, Ochi, Marika, Kumata, Keisuke, Sano, Hitoshi, Yoneda, Naohiro, Ueyama, Jun-ichi, Matsushita, Michiko, Kuwamoto, Satoshi, Kato, Masako, Murakami, Ichiro, Kanzaki, Susumu, Hayashi, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549369/
https://www.ncbi.nlm.nih.gov/pubmed/26322262
http://dx.doi.org/10.1186/s40064-015-1236-8
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author Nagata, Keiko
Okuno, Keisuke
Ochi, Marika
Kumata, Keisuke
Sano, Hitoshi
Yoneda, Naohiro
Ueyama, Jun-ichi
Matsushita, Michiko
Kuwamoto, Satoshi
Kato, Masako
Murakami, Ichiro
Kanzaki, Susumu
Hayashi, Kazuhiko
author_facet Nagata, Keiko
Okuno, Keisuke
Ochi, Marika
Kumata, Keisuke
Sano, Hitoshi
Yoneda, Naohiro
Ueyama, Jun-ichi
Matsushita, Michiko
Kuwamoto, Satoshi
Kato, Masako
Murakami, Ichiro
Kanzaki, Susumu
Hayashi, Kazuhiko
author_sort Nagata, Keiko
collection PubMed
description Various autoantibodies have been reported to be detected during the progression of infectious mononucleosis. We observed a case of infectious mononucleosis due to Epstein–Barr virus primary infection for 2 months, and noticed the transiently increased titer of thyrotropin receptor autoantibodies detected at the acute phase on the 3rd day after admission. At that time, real-time quantitative PCR also revealed the mRNA expressions of an immediate early lytic gene, BZLF1, and a latent gene, EBNA2. The expression of BZLF1 mRNA means that Epstein–Barr virus infects lytically, and EBNA2 protein has an important role in antibody production as well as the establishment of Epstein–Barr virus latency. These results suggest that Epstein–Barr virus lytic infection is relevant to thyrotropin receptor autoantibody production. Thyrotropin receptor autoantibodies stimulate thyroid follicular cells to produce excessive thyroid hormones and cause Graves’ disease. Recently, we reported the thyrotropin receptor autoantibody production from thyrotropin receptor autoantibody-predisposed Epstein–Barr virus-infected B cells by the induction of Epstein–Barr virus lytic infection in vitro. This case showed in vivo findings consistent with our previous reports, and is important to consider the pathophysiology of Graves’ disease and one of the mechanisms of autoimmunity.
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spelling pubmed-45493692015-08-28 Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child Nagata, Keiko Okuno, Keisuke Ochi, Marika Kumata, Keisuke Sano, Hitoshi Yoneda, Naohiro Ueyama, Jun-ichi Matsushita, Michiko Kuwamoto, Satoshi Kato, Masako Murakami, Ichiro Kanzaki, Susumu Hayashi, Kazuhiko Springerplus Case Study Various autoantibodies have been reported to be detected during the progression of infectious mononucleosis. We observed a case of infectious mononucleosis due to Epstein–Barr virus primary infection for 2 months, and noticed the transiently increased titer of thyrotropin receptor autoantibodies detected at the acute phase on the 3rd day after admission. At that time, real-time quantitative PCR also revealed the mRNA expressions of an immediate early lytic gene, BZLF1, and a latent gene, EBNA2. The expression of BZLF1 mRNA means that Epstein–Barr virus infects lytically, and EBNA2 protein has an important role in antibody production as well as the establishment of Epstein–Barr virus latency. These results suggest that Epstein–Barr virus lytic infection is relevant to thyrotropin receptor autoantibody production. Thyrotropin receptor autoantibodies stimulate thyroid follicular cells to produce excessive thyroid hormones and cause Graves’ disease. Recently, we reported the thyrotropin receptor autoantibody production from thyrotropin receptor autoantibody-predisposed Epstein–Barr virus-infected B cells by the induction of Epstein–Barr virus lytic infection in vitro. This case showed in vivo findings consistent with our previous reports, and is important to consider the pathophysiology of Graves’ disease and one of the mechanisms of autoimmunity. Springer International Publishing 2015-08-27 /pmc/articles/PMC4549369/ /pubmed/26322262 http://dx.doi.org/10.1186/s40064-015-1236-8 Text en © Nagata et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Study
Nagata, Keiko
Okuno, Keisuke
Ochi, Marika
Kumata, Keisuke
Sano, Hitoshi
Yoneda, Naohiro
Ueyama, Jun-ichi
Matsushita, Michiko
Kuwamoto, Satoshi
Kato, Masako
Murakami, Ichiro
Kanzaki, Susumu
Hayashi, Kazuhiko
Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child
title Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child
title_full Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child
title_fullStr Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child
title_full_unstemmed Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child
title_short Production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to Epstein–Barr virus primary infection: a case report of a child
title_sort production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to epstein–barr virus primary infection: a case report of a child
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549369/
https://www.ncbi.nlm.nih.gov/pubmed/26322262
http://dx.doi.org/10.1186/s40064-015-1236-8
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