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Extrastriate projections in human optic radiation revealed by fMRI-informed tractography

The human optic radiation (OR) is the main pathway for conveying visual input to occipital cortex, but it is unclear whether it projects beyond primary visual cortex (V1). In this study, we used functional MRI mapping to delineate early visual areas in 30 healthy volunteers and determined the termin...

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Detalles Bibliográficos
Autores principales: Alvarez, Ivan, Schwarzkopf, D. Samuel, Clark, Chris A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549382/
https://www.ncbi.nlm.nih.gov/pubmed/24903826
http://dx.doi.org/10.1007/s00429-014-0799-4
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author Alvarez, Ivan
Schwarzkopf, D. Samuel
Clark, Chris A.
author_facet Alvarez, Ivan
Schwarzkopf, D. Samuel
Clark, Chris A.
author_sort Alvarez, Ivan
collection PubMed
description The human optic radiation (OR) is the main pathway for conveying visual input to occipital cortex, but it is unclear whether it projects beyond primary visual cortex (V1). In this study, we used functional MRI mapping to delineate early visual areas in 30 healthy volunteers and determined the termination area of the OR as reconstructed with diffusion tractography. Direct thalamo-cortical projections to areas V2 and V3 were found in all hemispheres tested, with a distinct anatomical arrangement of superior–inferior fiber placement for dorsal and ventral projections, respectively, and a medio-lateral nesting arrangement for projections to V1, V2 and V3. Finally, segment-specific microstructure was examined, revealing sub-fascicular information. This is to date the first in vivo demonstration of direct extrastriate projections of the OR in humans.
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spelling pubmed-45493822015-08-27 Extrastriate projections in human optic radiation revealed by fMRI-informed tractography Alvarez, Ivan Schwarzkopf, D. Samuel Clark, Chris A. Brain Struct Funct Original Article The human optic radiation (OR) is the main pathway for conveying visual input to occipital cortex, but it is unclear whether it projects beyond primary visual cortex (V1). In this study, we used functional MRI mapping to delineate early visual areas in 30 healthy volunteers and determined the termination area of the OR as reconstructed with diffusion tractography. Direct thalamo-cortical projections to areas V2 and V3 were found in all hemispheres tested, with a distinct anatomical arrangement of superior–inferior fiber placement for dorsal and ventral projections, respectively, and a medio-lateral nesting arrangement for projections to V1, V2 and V3. Finally, segment-specific microstructure was examined, revealing sub-fascicular information. This is to date the first in vivo demonstration of direct extrastriate projections of the OR in humans. Springer Berlin Heidelberg 2014-06-06 2015 /pmc/articles/PMC4549382/ /pubmed/24903826 http://dx.doi.org/10.1007/s00429-014-0799-4 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Alvarez, Ivan
Schwarzkopf, D. Samuel
Clark, Chris A.
Extrastriate projections in human optic radiation revealed by fMRI-informed tractography
title Extrastriate projections in human optic radiation revealed by fMRI-informed tractography
title_full Extrastriate projections in human optic radiation revealed by fMRI-informed tractography
title_fullStr Extrastriate projections in human optic radiation revealed by fMRI-informed tractography
title_full_unstemmed Extrastriate projections in human optic radiation revealed by fMRI-informed tractography
title_short Extrastriate projections in human optic radiation revealed by fMRI-informed tractography
title_sort extrastriate projections in human optic radiation revealed by fmri-informed tractography
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549382/
https://www.ncbi.nlm.nih.gov/pubmed/24903826
http://dx.doi.org/10.1007/s00429-014-0799-4
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