Cargando…

Identification of neural firing patterns, frequency and temporal coding mechanisms in individual aortic baroreceptors

In rabbit depressor nerve fibers, an on-off firing pattern, period-1 firing, and integer multiple firing with quiescent state were observed as the static pressure level was increased. A bursting pattern with bursts at the systolic phase of blood pressure, continuous firing, and bursting with burst a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Huaguang, Pan, Baobao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549627/
https://www.ncbi.nlm.nih.gov/pubmed/26379539
http://dx.doi.org/10.3389/fncom.2015.00108
_version_ 1782387339398479872
author Gu, Huaguang
Pan, Baobao
author_facet Gu, Huaguang
Pan, Baobao
author_sort Gu, Huaguang
collection PubMed
description In rabbit depressor nerve fibers, an on-off firing pattern, period-1 firing, and integer multiple firing with quiescent state were observed as the static pressure level was increased. A bursting pattern with bursts at the systolic phase of blood pressure, continuous firing, and bursting with burst at diastolic phase and quiescent state at systolic phase were observed as the mean level of the dynamic blood pressure was increased. For both static and dynamic pressures, the firing frequency of the first two firing patterns increased and of the last firing pattern decreased due to the quiescent state. If the quiescent state is disregarded, the spike frequency becomes an increasing trend. The instantaneous spike frequency of the systolic phase bursting, continuous firing, and diastolic phase bursting can reflect the temporal process of the systolic phase, whole procedure, and diastolic phase of the dynamic blood pressure signal, respectively. With increasing the static current corresponding to pressure level, the deterministic Hodgkin-Huxley (HH) model manifests a process from a resting state first to period-1 firing via a subcritical Hopf bifurcation and then to a resting state via a supercritical Hopf bifurcation, and the firing frequency increases. The on-off firing and integer multiple firing were here identified as noise-induced firing patterns near the subcritical and supercritical Hopf bifurcation points, respectively, using the stochastic HH model. The systolic phase bursting and diastolic phase bursting were identified as pressure-induced firings near the subcritical and supercritical Hopf bifurcation points, respectively, using an HH model with a dynamic signal. The firing, spike frequency, and instantaneous spike frequency observed in the experiment were simulated and explained using HH models. The results illustrate the dynamics of different firing patterns and the frequency and temporal coding mechanisms of aortic baroreceptor.
format Online
Article
Text
id pubmed-4549627
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-45496272015-09-14 Identification of neural firing patterns, frequency and temporal coding mechanisms in individual aortic baroreceptors Gu, Huaguang Pan, Baobao Front Comput Neurosci Neuroscience In rabbit depressor nerve fibers, an on-off firing pattern, period-1 firing, and integer multiple firing with quiescent state were observed as the static pressure level was increased. A bursting pattern with bursts at the systolic phase of blood pressure, continuous firing, and bursting with burst at diastolic phase and quiescent state at systolic phase were observed as the mean level of the dynamic blood pressure was increased. For both static and dynamic pressures, the firing frequency of the first two firing patterns increased and of the last firing pattern decreased due to the quiescent state. If the quiescent state is disregarded, the spike frequency becomes an increasing trend. The instantaneous spike frequency of the systolic phase bursting, continuous firing, and diastolic phase bursting can reflect the temporal process of the systolic phase, whole procedure, and diastolic phase of the dynamic blood pressure signal, respectively. With increasing the static current corresponding to pressure level, the deterministic Hodgkin-Huxley (HH) model manifests a process from a resting state first to period-1 firing via a subcritical Hopf bifurcation and then to a resting state via a supercritical Hopf bifurcation, and the firing frequency increases. The on-off firing and integer multiple firing were here identified as noise-induced firing patterns near the subcritical and supercritical Hopf bifurcation points, respectively, using the stochastic HH model. The systolic phase bursting and diastolic phase bursting were identified as pressure-induced firings near the subcritical and supercritical Hopf bifurcation points, respectively, using an HH model with a dynamic signal. The firing, spike frequency, and instantaneous spike frequency observed in the experiment were simulated and explained using HH models. The results illustrate the dynamics of different firing patterns and the frequency and temporal coding mechanisms of aortic baroreceptor. Frontiers Media S.A. 2015-08-26 /pmc/articles/PMC4549627/ /pubmed/26379539 http://dx.doi.org/10.3389/fncom.2015.00108 Text en Copyright © 2015 Gu and Pan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gu, Huaguang
Pan, Baobao
Identification of neural firing patterns, frequency and temporal coding mechanisms in individual aortic baroreceptors
title Identification of neural firing patterns, frequency and temporal coding mechanisms in individual aortic baroreceptors
title_full Identification of neural firing patterns, frequency and temporal coding mechanisms in individual aortic baroreceptors
title_fullStr Identification of neural firing patterns, frequency and temporal coding mechanisms in individual aortic baroreceptors
title_full_unstemmed Identification of neural firing patterns, frequency and temporal coding mechanisms in individual aortic baroreceptors
title_short Identification of neural firing patterns, frequency and temporal coding mechanisms in individual aortic baroreceptors
title_sort identification of neural firing patterns, frequency and temporal coding mechanisms in individual aortic baroreceptors
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549627/
https://www.ncbi.nlm.nih.gov/pubmed/26379539
http://dx.doi.org/10.3389/fncom.2015.00108
work_keys_str_mv AT guhuaguang identificationofneuralfiringpatternsfrequencyandtemporalcodingmechanismsinindividualaorticbaroreceptors
AT panbaobao identificationofneuralfiringpatternsfrequencyandtemporalcodingmechanismsinindividualaorticbaroreceptors