An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12

The proinflammatory cytokine IL-12 drives the generation of terminally differentiated KLRG1(+) effector CD8(+) T cells. Using a Toxoplasma vaccination model, we delineate the sequence of events that naïve CD8(+) T cells undergo to become terminal effectors and the differentiation steps controlled by...

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Detalles Bibliográficos
Autores principales: Shah, Suhagi, Grotenbreg, Gijsbert M, Rivera, Amariliz, Yap, George S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549662/
https://www.ncbi.nlm.nih.gov/pubmed/26244629
http://dx.doi.org/10.7554/eLife.09017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549662/
https://www.ncbi.nlm.nih.gov/pubmed/26244629
http://dx.doi.org/10.7554/eLife.09017

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