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Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent

Deoxynivalenol (DON, vomitoxin), a common trichothecene mycotoxin found in cereal foods, dysregulates immune function and maintenance of energy balance. The purpose of this study was to determine if sex differences are similarly evident in DON’s anorectic responses in mice. A bioassay for feed refus...

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Detalles Bibliográficos
Autores principales: Clark, Erica S., Flannery, Brenna M., Pestka, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549728/
https://www.ncbi.nlm.nih.gov/pubmed/26230710
http://dx.doi.org/10.3390/toxins7082845
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author Clark, Erica S.
Flannery, Brenna M.
Pestka, James J.
author_facet Clark, Erica S.
Flannery, Brenna M.
Pestka, James J.
author_sort Clark, Erica S.
collection PubMed
description Deoxynivalenol (DON, vomitoxin), a common trichothecene mycotoxin found in cereal foods, dysregulates immune function and maintenance of energy balance. The purpose of this study was to determine if sex differences are similarly evident in DON’s anorectic responses in mice. A bioassay for feed refusal, previously developed by our lab, was used to compare acute i.p. exposures of 1 and 5 mg/kg bw DON in C57BL6 mice. Greater anorectic responses were seen in male than female mice. Male mice had higher organ and plasma concentrations of DON upon acute exposure than their female counterparts. A significant increase in IL-6 plasma levels was also observed in males while cholecystokinin response was higher in females. When effects of sex on food intake and body weight changes were compared after subchronic dietary exposure to 1, 2.5, and 10 ppm DON, males were found again to be more sensitive. Demonstration of male predilection to DON-induced changes in food intake and weight gain might an important consideration in future risk assessment of DON and other trichothecenes.
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spelling pubmed-45497282015-08-31 Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent Clark, Erica S. Flannery, Brenna M. Pestka, James J. Toxins (Basel) Article Deoxynivalenol (DON, vomitoxin), a common trichothecene mycotoxin found in cereal foods, dysregulates immune function and maintenance of energy balance. The purpose of this study was to determine if sex differences are similarly evident in DON’s anorectic responses in mice. A bioassay for feed refusal, previously developed by our lab, was used to compare acute i.p. exposures of 1 and 5 mg/kg bw DON in C57BL6 mice. Greater anorectic responses were seen in male than female mice. Male mice had higher organ and plasma concentrations of DON upon acute exposure than their female counterparts. A significant increase in IL-6 plasma levels was also observed in males while cholecystokinin response was higher in females. When effects of sex on food intake and body weight changes were compared after subchronic dietary exposure to 1, 2.5, and 10 ppm DON, males were found again to be more sensitive. Demonstration of male predilection to DON-induced changes in food intake and weight gain might an important consideration in future risk assessment of DON and other trichothecenes. MDPI 2015-07-29 /pmc/articles/PMC4549728/ /pubmed/26230710 http://dx.doi.org/10.3390/toxins7082845 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Clark, Erica S.
Flannery, Brenna M.
Pestka, James J.
Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent
title Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent
title_full Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent
title_fullStr Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent
title_full_unstemmed Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent
title_short Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent
title_sort murine anorectic response to deoxynivalenol (vomitoxin) is sex-dependent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549728/
https://www.ncbi.nlm.nih.gov/pubmed/26230710
http://dx.doi.org/10.3390/toxins7082845
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