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Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent
Deoxynivalenol (DON, vomitoxin), a common trichothecene mycotoxin found in cereal foods, dysregulates immune function and maintenance of energy balance. The purpose of this study was to determine if sex differences are similarly evident in DON’s anorectic responses in mice. A bioassay for feed refus...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549728/ https://www.ncbi.nlm.nih.gov/pubmed/26230710 http://dx.doi.org/10.3390/toxins7082845 |
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author | Clark, Erica S. Flannery, Brenna M. Pestka, James J. |
author_facet | Clark, Erica S. Flannery, Brenna M. Pestka, James J. |
author_sort | Clark, Erica S. |
collection | PubMed |
description | Deoxynivalenol (DON, vomitoxin), a common trichothecene mycotoxin found in cereal foods, dysregulates immune function and maintenance of energy balance. The purpose of this study was to determine if sex differences are similarly evident in DON’s anorectic responses in mice. A bioassay for feed refusal, previously developed by our lab, was used to compare acute i.p. exposures of 1 and 5 mg/kg bw DON in C57BL6 mice. Greater anorectic responses were seen in male than female mice. Male mice had higher organ and plasma concentrations of DON upon acute exposure than their female counterparts. A significant increase in IL-6 plasma levels was also observed in males while cholecystokinin response was higher in females. When effects of sex on food intake and body weight changes were compared after subchronic dietary exposure to 1, 2.5, and 10 ppm DON, males were found again to be more sensitive. Demonstration of male predilection to DON-induced changes in food intake and weight gain might an important consideration in future risk assessment of DON and other trichothecenes. |
format | Online Article Text |
id | pubmed-4549728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45497282015-08-31 Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent Clark, Erica S. Flannery, Brenna M. Pestka, James J. Toxins (Basel) Article Deoxynivalenol (DON, vomitoxin), a common trichothecene mycotoxin found in cereal foods, dysregulates immune function and maintenance of energy balance. The purpose of this study was to determine if sex differences are similarly evident in DON’s anorectic responses in mice. A bioassay for feed refusal, previously developed by our lab, was used to compare acute i.p. exposures of 1 and 5 mg/kg bw DON in C57BL6 mice. Greater anorectic responses were seen in male than female mice. Male mice had higher organ and plasma concentrations of DON upon acute exposure than their female counterparts. A significant increase in IL-6 plasma levels was also observed in males while cholecystokinin response was higher in females. When effects of sex on food intake and body weight changes were compared after subchronic dietary exposure to 1, 2.5, and 10 ppm DON, males were found again to be more sensitive. Demonstration of male predilection to DON-induced changes in food intake and weight gain might an important consideration in future risk assessment of DON and other trichothecenes. MDPI 2015-07-29 /pmc/articles/PMC4549728/ /pubmed/26230710 http://dx.doi.org/10.3390/toxins7082845 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Clark, Erica S. Flannery, Brenna M. Pestka, James J. Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent |
title | Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent |
title_full | Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent |
title_fullStr | Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent |
title_full_unstemmed | Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent |
title_short | Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent |
title_sort | murine anorectic response to deoxynivalenol (vomitoxin) is sex-dependent |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549728/ https://www.ncbi.nlm.nih.gov/pubmed/26230710 http://dx.doi.org/10.3390/toxins7082845 |
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