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Metabolic engineering of Bacillus subtilis for redistributing the carbon flux to 2,3-butanediol by manipulating NADH levels

BACKGROUND: Acetoin reductase (Acr) catalyzes the conversion of acetoin to 2,3-butanediol (2,3-BD) with concomitant oxidation of NADH to NAD(+). Therefore, intracellular 2,3-BD production is likely governed by the quantities of rate-limiting factor(s) Acr and/or NADH. Previously, we showed that a hi...

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Detalles Bibliográficos
Autores principales:	Yang, Taowei, Rao, Zhiming, Hu, Guiyuan, Zhang, Xian, Liu, Mei, Dai, Yue, Xu, Meijuan, Xu, Zhenghong, Yang, Shang-Tian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549875/ https://www.ncbi.nlm.nih.gov/pubmed/26312069 http://dx.doi.org/10.1186/s13068-015-0320-1

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