Serum inflammatory markers in obese mice: Effect of ghrelin

BACKGROUND: Ghrelin is involved in modulation of food intake and energy homeostasis; however, it may play a role in cardiovascular system and atherosclerosis process. This study aimed to investigate the effect of ghrelin on serum inflammatory markers in control and obese mice. MATERIALS AND METHODS:...

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Detalles Bibliográficos
Autores principales: Khazaei, Majid, Tahergorabi, Zoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549929/
https://www.ncbi.nlm.nih.gov/pubmed/26322293
http://dx.doi.org/10.4103/2277-9175.161556
Descripción
Sumario:BACKGROUND: Ghrelin is involved in modulation of food intake and energy homeostasis; however, it may play a role in cardiovascular system and atherosclerosis process. This study aimed to investigate the effect of ghrelin on serum inflammatory markers in control and obese mice. MATERIALS AND METHODS: Ghrelin (100 mg/kg/day, twice daily) was administered interaperitoneally to control and diet-induced obese mice. After 10 days, blood samples were taken. RESULTS: Results showed that administration of ghrelin did not change serum hsCRP level; however, it reduced serum IL-6 concentration in obese mice (P < 0.05). CONCLUSION: It seems that the exact role and mechanism of ghrelin in prevention or treatment of atherosclerosis needs more studies.

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