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AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein–Protein Interaction Interfaces
[Image: see text] Inhibition of protein–protein interactions (PPIs) is emerging as a promising therapeutic strategy despite the difficulty in targeting such interfaces with drug-like small molecules. PPIs generally feature large and flat binding surfaces as compared to typical drug targets. These fe...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550072/ https://www.ncbi.nlm.nih.gov/pubmed/26225450 http://dx.doi.org/10.1021/acs.jcim.5b00103 |