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Mycobacterium abscessus Complex Infections in Humans
Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections. M. abscessus complex is di...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550155/ https://www.ncbi.nlm.nih.gov/pubmed/26295364 http://dx.doi.org/10.3201/2109.141634 |
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author | Lee, Meng-Rui Sheng, Wang-Huei Hung, Chien-Ching Yu, Chong-Jen Lee, Li-Na Hsueh, Po-Ren |
author_facet | Lee, Meng-Rui Sheng, Wang-Huei Hung, Chien-Ching Yu, Chong-Jen Lee, Li-Na Hsueh, Po-Ren |
author_sort | Lee, Meng-Rui |
collection | PubMed |
description | Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections. M. abscessus complex is differentiated into 3 subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. abscessus subsp. bolletii. The 2 major subspecies, M. abscessus subsp. abscessus and M. abscessus subsp. massiliense, have different erm(41) gene patterns. This gene provides intrinsic resistance to macrolides, so the different patterns lead to different treatment outcomes. M. abscessus complex outbreaks associated with cosmetic procedures and nosocomial transmissions are not uncommon. Clarithromycin, amikacin, and cefoxitin are the current antimicrobial drugs of choice for treatment. However, new treatment regimens are urgently needed, as are rapid and inexpensive identification methods and measures to contain nosocomial transmission and outbreaks. |
format | Online Article Text |
id | pubmed-4550155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-45501552015-09-01 Mycobacterium abscessus Complex Infections in Humans Lee, Meng-Rui Sheng, Wang-Huei Hung, Chien-Ching Yu, Chong-Jen Lee, Li-Na Hsueh, Po-Ren Emerg Infect Dis Synopsis Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections. M. abscessus complex is differentiated into 3 subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. abscessus subsp. bolletii. The 2 major subspecies, M. abscessus subsp. abscessus and M. abscessus subsp. massiliense, have different erm(41) gene patterns. This gene provides intrinsic resistance to macrolides, so the different patterns lead to different treatment outcomes. M. abscessus complex outbreaks associated with cosmetic procedures and nosocomial transmissions are not uncommon. Clarithromycin, amikacin, and cefoxitin are the current antimicrobial drugs of choice for treatment. However, new treatment regimens are urgently needed, as are rapid and inexpensive identification methods and measures to contain nosocomial transmission and outbreaks. Centers for Disease Control and Prevention 2015-09 /pmc/articles/PMC4550155/ /pubmed/26295364 http://dx.doi.org/10.3201/2109.141634 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Synopsis Lee, Meng-Rui Sheng, Wang-Huei Hung, Chien-Ching Yu, Chong-Jen Lee, Li-Na Hsueh, Po-Ren Mycobacterium abscessus Complex Infections in Humans |
title | Mycobacterium abscessus Complex Infections in Humans |
title_full | Mycobacterium abscessus Complex Infections in Humans |
title_fullStr | Mycobacterium abscessus Complex Infections in Humans |
title_full_unstemmed | Mycobacterium abscessus Complex Infections in Humans |
title_short | Mycobacterium abscessus Complex Infections in Humans |
title_sort | mycobacterium abscessus complex infections in humans |
topic | Synopsis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550155/ https://www.ncbi.nlm.nih.gov/pubmed/26295364 http://dx.doi.org/10.3201/2109.141634 |
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