Disruption of NF-κB signaling by fluoxetine attenuates MGMT expression in glioma cells

BACKGROUND: Resistance to temozolomide (TMZ) in glioma is modulated by the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). This study aimed to examine the effects of fluoxetine (FLT) on MGMT expression in glioma cells and to investigate its underlying mechanisms. MATERIALS AND METH...

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Detalles Bibliográficos
Autores principales: Song, Tao, Li, Hui, Tian, Zhiliang, Xu, Chaojiu, Liu, Jingfang, Guo, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550181/
https://www.ncbi.nlm.nih.gov/pubmed/26346978
http://dx.doi.org/10.2147/OTT.S85948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550181/
https://www.ncbi.nlm.nih.gov/pubmed/26346978
http://dx.doi.org/10.2147/OTT.S85948

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