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Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis

OBJECTIVE: Apolipoprotein A5 (APOA5) is associated with plasma triglyceride (TG) levels, a risk factor for coronary heart disease (CHD). This study explored the association between CHD and the APOA5 rs662799 polymorphism. METHODS: We collected 1,521 samples (783 CHD patients and 738 controls) for th...

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Autores principales: Ye, Huadan, Zhou, Annan, Hong, Qiangxiao, Tang, Linlin, Xu, Xuting, Xin, Yanfei, Jiang, Danjie, Dai, Dongjun, Li, Yirun, Wang, Dao Wen, Duan, Shiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550406/
https://www.ncbi.nlm.nih.gov/pubmed/26309253
http://dx.doi.org/10.1371/journal.pone.0135683
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author Ye, Huadan
Zhou, Annan
Hong, Qiangxiao
Tang, Linlin
Xu, Xuting
Xin, Yanfei
Jiang, Danjie
Dai, Dongjun
Li, Yirun
Wang, Dao Wen
Duan, Shiwei
author_facet Ye, Huadan
Zhou, Annan
Hong, Qiangxiao
Tang, Linlin
Xu, Xuting
Xin, Yanfei
Jiang, Danjie
Dai, Dongjun
Li, Yirun
Wang, Dao Wen
Duan, Shiwei
author_sort Ye, Huadan
collection PubMed
description OBJECTIVE: Apolipoprotein A5 (APOA5) is associated with plasma triglyceride (TG) levels, a risk factor for coronary heart disease (CHD). This study explored the association between CHD and the APOA5 rs662799 polymorphism. METHODS: We collected 1,521 samples (783 CHD patients and 738 controls) for this case-control study. Meta-analysis was performed using Review Manager Software and Stata Software. RESULTS: Significant differences were observed between CHD cases and controls at the level of both genotype (χ(2) = 8.964, df = 2, P = 0.011) and allele (χ(2) = 9.180, df = 1, P = 0.002, OR = 1.275, 95% CI = 1.089–1.492). A breakdown analysis by gender showed a significant association of APOA5 rs662799 with CHD in males (χ(2) = 7.770, df = 1, P = 0.005; OR = 1.331, 95% CI = 1.088–1.628). An additional meta-analysis using 21378 cases and 28428 controls established that rs662799 is significantly associated with CHD (P < 0.00001). CONCLUSION: Both our case-control study and meta-analysis confirm a significant association between APOA5 rs662799 and CHD. In addition, our results suggest a male-specific association between the APOA5 rs662799 polymorphism and CHD.
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spelling pubmed-45504062015-09-01 Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis Ye, Huadan Zhou, Annan Hong, Qiangxiao Tang, Linlin Xu, Xuting Xin, Yanfei Jiang, Danjie Dai, Dongjun Li, Yirun Wang, Dao Wen Duan, Shiwei PLoS One Research Article OBJECTIVE: Apolipoprotein A5 (APOA5) is associated with plasma triglyceride (TG) levels, a risk factor for coronary heart disease (CHD). This study explored the association between CHD and the APOA5 rs662799 polymorphism. METHODS: We collected 1,521 samples (783 CHD patients and 738 controls) for this case-control study. Meta-analysis was performed using Review Manager Software and Stata Software. RESULTS: Significant differences were observed between CHD cases and controls at the level of both genotype (χ(2) = 8.964, df = 2, P = 0.011) and allele (χ(2) = 9.180, df = 1, P = 0.002, OR = 1.275, 95% CI = 1.089–1.492). A breakdown analysis by gender showed a significant association of APOA5 rs662799 with CHD in males (χ(2) = 7.770, df = 1, P = 0.005; OR = 1.331, 95% CI = 1.088–1.628). An additional meta-analysis using 21378 cases and 28428 controls established that rs662799 is significantly associated with CHD (P < 0.00001). CONCLUSION: Both our case-control study and meta-analysis confirm a significant association between APOA5 rs662799 and CHD. In addition, our results suggest a male-specific association between the APOA5 rs662799 polymorphism and CHD. Public Library of Science 2015-08-26 /pmc/articles/PMC4550406/ /pubmed/26309253 http://dx.doi.org/10.1371/journal.pone.0135683 Text en © 2015 Ye et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ye, Huadan
Zhou, Annan
Hong, Qiangxiao
Tang, Linlin
Xu, Xuting
Xin, Yanfei
Jiang, Danjie
Dai, Dongjun
Li, Yirun
Wang, Dao Wen
Duan, Shiwei
Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis
title Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis
title_full Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis
title_fullStr Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis
title_full_unstemmed Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis
title_short Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis
title_sort positive association between apoa5 rs662799 polymorphism and coronary heart disease: a case-control study and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550406/
https://www.ncbi.nlm.nih.gov/pubmed/26309253
http://dx.doi.org/10.1371/journal.pone.0135683
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