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Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis
OBJECTIVE: Apolipoprotein A5 (APOA5) is associated with plasma triglyceride (TG) levels, a risk factor for coronary heart disease (CHD). This study explored the association between CHD and the APOA5 rs662799 polymorphism. METHODS: We collected 1,521 samples (783 CHD patients and 738 controls) for th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550406/ https://www.ncbi.nlm.nih.gov/pubmed/26309253 http://dx.doi.org/10.1371/journal.pone.0135683 |
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author | Ye, Huadan Zhou, Annan Hong, Qiangxiao Tang, Linlin Xu, Xuting Xin, Yanfei Jiang, Danjie Dai, Dongjun Li, Yirun Wang, Dao Wen Duan, Shiwei |
author_facet | Ye, Huadan Zhou, Annan Hong, Qiangxiao Tang, Linlin Xu, Xuting Xin, Yanfei Jiang, Danjie Dai, Dongjun Li, Yirun Wang, Dao Wen Duan, Shiwei |
author_sort | Ye, Huadan |
collection | PubMed |
description | OBJECTIVE: Apolipoprotein A5 (APOA5) is associated with plasma triglyceride (TG) levels, a risk factor for coronary heart disease (CHD). This study explored the association between CHD and the APOA5 rs662799 polymorphism. METHODS: We collected 1,521 samples (783 CHD patients and 738 controls) for this case-control study. Meta-analysis was performed using Review Manager Software and Stata Software. RESULTS: Significant differences were observed between CHD cases and controls at the level of both genotype (χ(2) = 8.964, df = 2, P = 0.011) and allele (χ(2) = 9.180, df = 1, P = 0.002, OR = 1.275, 95% CI = 1.089–1.492). A breakdown analysis by gender showed a significant association of APOA5 rs662799 with CHD in males (χ(2) = 7.770, df = 1, P = 0.005; OR = 1.331, 95% CI = 1.088–1.628). An additional meta-analysis using 21378 cases and 28428 controls established that rs662799 is significantly associated with CHD (P < 0.00001). CONCLUSION: Both our case-control study and meta-analysis confirm a significant association between APOA5 rs662799 and CHD. In addition, our results suggest a male-specific association between the APOA5 rs662799 polymorphism and CHD. |
format | Online Article Text |
id | pubmed-4550406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45504062015-09-01 Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis Ye, Huadan Zhou, Annan Hong, Qiangxiao Tang, Linlin Xu, Xuting Xin, Yanfei Jiang, Danjie Dai, Dongjun Li, Yirun Wang, Dao Wen Duan, Shiwei PLoS One Research Article OBJECTIVE: Apolipoprotein A5 (APOA5) is associated with plasma triglyceride (TG) levels, a risk factor for coronary heart disease (CHD). This study explored the association between CHD and the APOA5 rs662799 polymorphism. METHODS: We collected 1,521 samples (783 CHD patients and 738 controls) for this case-control study. Meta-analysis was performed using Review Manager Software and Stata Software. RESULTS: Significant differences were observed between CHD cases and controls at the level of both genotype (χ(2) = 8.964, df = 2, P = 0.011) and allele (χ(2) = 9.180, df = 1, P = 0.002, OR = 1.275, 95% CI = 1.089–1.492). A breakdown analysis by gender showed a significant association of APOA5 rs662799 with CHD in males (χ(2) = 7.770, df = 1, P = 0.005; OR = 1.331, 95% CI = 1.088–1.628). An additional meta-analysis using 21378 cases and 28428 controls established that rs662799 is significantly associated with CHD (P < 0.00001). CONCLUSION: Both our case-control study and meta-analysis confirm a significant association between APOA5 rs662799 and CHD. In addition, our results suggest a male-specific association between the APOA5 rs662799 polymorphism and CHD. Public Library of Science 2015-08-26 /pmc/articles/PMC4550406/ /pubmed/26309253 http://dx.doi.org/10.1371/journal.pone.0135683 Text en © 2015 Ye et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Ye, Huadan Zhou, Annan Hong, Qiangxiao Tang, Linlin Xu, Xuting Xin, Yanfei Jiang, Danjie Dai, Dongjun Li, Yirun Wang, Dao Wen Duan, Shiwei Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis |
title | Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis |
title_full | Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis |
title_fullStr | Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis |
title_full_unstemmed | Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis |
title_short | Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis |
title_sort | positive association between apoa5 rs662799 polymorphism and coronary heart disease: a case-control study and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550406/ https://www.ncbi.nlm.nih.gov/pubmed/26309253 http://dx.doi.org/10.1371/journal.pone.0135683 |
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