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Cancer Visibility among Iranian Familial Networks: To What Extent Can We Rely on Family History Reports?

OBJECTIVE: Patients’ unawareness of their cancer diagnosis (PUAW) and their tendency for non-disclosure (TTND) to relatives leads to a lack of cancer visibility among familial networks. Lack of familial cancer visibility could affect the accuracy of family cancer history (FCH) reports. In this study...

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Autores principales: Molavi Vardanjani, Hossein, Baneshi, Mohammad Reza, Haghdoost, AliAkbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550411/
https://www.ncbi.nlm.nih.gov/pubmed/26308087
http://dx.doi.org/10.1371/journal.pone.0136038
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author Molavi Vardanjani, Hossein
Baneshi, Mohammad Reza
Haghdoost, AliAkbar
author_facet Molavi Vardanjani, Hossein
Baneshi, Mohammad Reza
Haghdoost, AliAkbar
author_sort Molavi Vardanjani, Hossein
collection PubMed
description OBJECTIVE: Patients’ unawareness of their cancer diagnosis (PUAW) and their tendency for non-disclosure (TTND) to relatives leads to a lack of cancer visibility among familial networks. Lack of familial cancer visibility could affect the accuracy of family cancer history (FCH) reports. In this study, we investigated familial cancer visibility and its potential determinants. PATIENTS AND METHODS: A sample of patients with a confirmed cancer diagnosis was interviewed. Participants were asked about their number of relatives, number of their relatives who are aware about the cancer diagnosis, and the number of relatives from whom they intended to conceal their diagnosis. PUAW was also assessed. Point estimates and 95% confidence intervals were calculated using the bootstrap technique. Multivariate analyses were conducted using mixed Poisson and logistic regression analyses. RESULTS: A total of 415 participants with a mean age of 53±15 years and a male to female ratio of 0.53 were enrolled in this study. The rates of PUAW, TTND, and familial cancer visibility in the total sample were 0.20 (95% confidence interval (CI): 0.16, 0.24), 0.16 (95% CI: 0.12, 0.19), and 0.86 (95% CI: 0.83, 0.89), respectively. PUAW (adjusted rate ratio (RR) = 1.32, 95% CI: 1.27, 1.38), TTND (RR = 0.92, 95% CI: 0.91, 0.93), and the patients’ gender (RR = 0.92, 95% CI: 0.82, 0.95) were the most important determinants of familial cancer visibility. CONCLUSION: Familial cancer visibility may be a point of concern among the Iranian population. Self-reported cancer histories and FCHs may have low sensitivities (not exceeding 80% and 86%, respectively) in this population. However, these estimates may vary across different societies, because of societal and cultural contexts.
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spelling pubmed-45504112015-09-01 Cancer Visibility among Iranian Familial Networks: To What Extent Can We Rely on Family History Reports? Molavi Vardanjani, Hossein Baneshi, Mohammad Reza Haghdoost, AliAkbar PLoS One Research Article OBJECTIVE: Patients’ unawareness of their cancer diagnosis (PUAW) and their tendency for non-disclosure (TTND) to relatives leads to a lack of cancer visibility among familial networks. Lack of familial cancer visibility could affect the accuracy of family cancer history (FCH) reports. In this study, we investigated familial cancer visibility and its potential determinants. PATIENTS AND METHODS: A sample of patients with a confirmed cancer diagnosis was interviewed. Participants were asked about their number of relatives, number of their relatives who are aware about the cancer diagnosis, and the number of relatives from whom they intended to conceal their diagnosis. PUAW was also assessed. Point estimates and 95% confidence intervals were calculated using the bootstrap technique. Multivariate analyses were conducted using mixed Poisson and logistic regression analyses. RESULTS: A total of 415 participants with a mean age of 53±15 years and a male to female ratio of 0.53 were enrolled in this study. The rates of PUAW, TTND, and familial cancer visibility in the total sample were 0.20 (95% confidence interval (CI): 0.16, 0.24), 0.16 (95% CI: 0.12, 0.19), and 0.86 (95% CI: 0.83, 0.89), respectively. PUAW (adjusted rate ratio (RR) = 1.32, 95% CI: 1.27, 1.38), TTND (RR = 0.92, 95% CI: 0.91, 0.93), and the patients’ gender (RR = 0.92, 95% CI: 0.82, 0.95) were the most important determinants of familial cancer visibility. CONCLUSION: Familial cancer visibility may be a point of concern among the Iranian population. Self-reported cancer histories and FCHs may have low sensitivities (not exceeding 80% and 86%, respectively) in this population. However, these estimates may vary across different societies, because of societal and cultural contexts. Public Library of Science 2015-08-26 /pmc/articles/PMC4550411/ /pubmed/26308087 http://dx.doi.org/10.1371/journal.pone.0136038 Text en © 2015 Molavi Vardanjani et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Molavi Vardanjani, Hossein
Baneshi, Mohammad Reza
Haghdoost, AliAkbar
Cancer Visibility among Iranian Familial Networks: To What Extent Can We Rely on Family History Reports?
title Cancer Visibility among Iranian Familial Networks: To What Extent Can We Rely on Family History Reports?
title_full Cancer Visibility among Iranian Familial Networks: To What Extent Can We Rely on Family History Reports?
title_fullStr Cancer Visibility among Iranian Familial Networks: To What Extent Can We Rely on Family History Reports?
title_full_unstemmed Cancer Visibility among Iranian Familial Networks: To What Extent Can We Rely on Family History Reports?
title_short Cancer Visibility among Iranian Familial Networks: To What Extent Can We Rely on Family History Reports?
title_sort cancer visibility among iranian familial networks: to what extent can we rely on family history reports?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550411/
https://www.ncbi.nlm.nih.gov/pubmed/26308087
http://dx.doi.org/10.1371/journal.pone.0136038
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