A Novel Isoquinoline Derivative Anticancer Agent and Its Targeted Delivery to Tumor Cells Using Transferrin-Conjugated Liposomes

We have screened 11 isoquinoline derivatives and α-methylene-γ-butyrolactones using the 3-(4,5-dimethylthi-azol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay in HeLa and HEK-293T cells. Compound 2 was identified as potential anticancer agent. To further improve its therapeutic poten...

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Detalles Bibliográficos
Autores principales: Yang, Xuewei, Yang, Shuang, Chai, Hongyu, Yang, Zhaogang, Lee, Robert J., Liao, Weiwei, Teng, Lesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550422/
https://www.ncbi.nlm.nih.gov/pubmed/26309138
http://dx.doi.org/10.1371/journal.pone.0136649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550422/
https://www.ncbi.nlm.nih.gov/pubmed/26309138
http://dx.doi.org/10.1371/journal.pone.0136649

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