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PSCA rs2294008 Polymorphism with Increased Risk of Cancer
BACKGROUND: Published data on the association between PSCA rs2294008 polymorphism and cancer risk have implicated inconclusive results. To determine the relationship and to precisely assess the effect size estimate of the association, we performed a meta-analysis. METHODS: We searched published lite...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550426/ https://www.ncbi.nlm.nih.gov/pubmed/26308216 http://dx.doi.org/10.1371/journal.pone.0136269 |
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author | Geng, Peiliang Li, Jianjun Wang, Ning Ou, Juanjuan Xie, Ganfeng Liu, Chen Zhao, Xiaoxin Xiang, Lisha Liao, Yunmei Liang, Houjie |
author_facet | Geng, Peiliang Li, Jianjun Wang, Ning Ou, Juanjuan Xie, Ganfeng Liu, Chen Zhao, Xiaoxin Xiang, Lisha Liao, Yunmei Liang, Houjie |
author_sort | Geng, Peiliang |
collection | PubMed |
description | BACKGROUND: Published data on the association between PSCA rs2294008 polymorphism and cancer risk have implicated inconclusive results. To determine the relationship and to precisely assess the effect size estimate of the association, we performed a meta-analysis. METHODS: We searched published literature in Embase and PubMed databases using the search terms “PSCA”, “prostate stem cell antigen”, “variants”, “polymorphism”, “polymorphisms”, and “cancer”. A total of 21 eligible articles were retrieved, with 27, 197 cancer cases and 48, 237 controls. RESULTS: On the whole, we found the association between PSCA rs2294008 polymorphism and cancer risk was statistically significant: TT vs CC: OR = 1.18, 95% CI, 1.10 to 1.27; TT + CT vs CC: OR = 1.08, 95% CI, 1.05 to 1.10; TT vs CT + CC: OR = 1.14, 95% CI, 1.07 to 1.21; T vs C: OR = 1.10, 95% CI, 1.06 to 1.14; CT vs CC: OR = 1.10, 95% CI, 1.06 to 1.13. Stratified analyses in cancer type and ethnicity showed similar results. CONCLUSIONS: Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer. |
format | Online Article Text |
id | pubmed-4550426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45504262015-09-01 PSCA rs2294008 Polymorphism with Increased Risk of Cancer Geng, Peiliang Li, Jianjun Wang, Ning Ou, Juanjuan Xie, Ganfeng Liu, Chen Zhao, Xiaoxin Xiang, Lisha Liao, Yunmei Liang, Houjie PLoS One Research Article BACKGROUND: Published data on the association between PSCA rs2294008 polymorphism and cancer risk have implicated inconclusive results. To determine the relationship and to precisely assess the effect size estimate of the association, we performed a meta-analysis. METHODS: We searched published literature in Embase and PubMed databases using the search terms “PSCA”, “prostate stem cell antigen”, “variants”, “polymorphism”, “polymorphisms”, and “cancer”. A total of 21 eligible articles were retrieved, with 27, 197 cancer cases and 48, 237 controls. RESULTS: On the whole, we found the association between PSCA rs2294008 polymorphism and cancer risk was statistically significant: TT vs CC: OR = 1.18, 95% CI, 1.10 to 1.27; TT + CT vs CC: OR = 1.08, 95% CI, 1.05 to 1.10; TT vs CT + CC: OR = 1.14, 95% CI, 1.07 to 1.21; T vs C: OR = 1.10, 95% CI, 1.06 to 1.14; CT vs CC: OR = 1.10, 95% CI, 1.06 to 1.13. Stratified analyses in cancer type and ethnicity showed similar results. CONCLUSIONS: Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer. Public Library of Science 2015-08-26 /pmc/articles/PMC4550426/ /pubmed/26308216 http://dx.doi.org/10.1371/journal.pone.0136269 Text en © 2015 Geng et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Geng, Peiliang Li, Jianjun Wang, Ning Ou, Juanjuan Xie, Ganfeng Liu, Chen Zhao, Xiaoxin Xiang, Lisha Liao, Yunmei Liang, Houjie PSCA rs2294008 Polymorphism with Increased Risk of Cancer |
title | PSCA rs2294008 Polymorphism with Increased Risk of Cancer |
title_full | PSCA rs2294008 Polymorphism with Increased Risk of Cancer |
title_fullStr | PSCA rs2294008 Polymorphism with Increased Risk of Cancer |
title_full_unstemmed | PSCA rs2294008 Polymorphism with Increased Risk of Cancer |
title_short | PSCA rs2294008 Polymorphism with Increased Risk of Cancer |
title_sort | psca rs2294008 polymorphism with increased risk of cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550426/ https://www.ncbi.nlm.nih.gov/pubmed/26308216 http://dx.doi.org/10.1371/journal.pone.0136269 |
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