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Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 Years Old

OBJECTIVE: To evaluate the association of birthweight and weight gain during different periods in childhood with the prevalence of hypertriglyceridemic waist phenotype (HWP). METHODS: In 1982, all hospitals births in Pelotas, South Brazil, were identified, and the 5914 liveborn were examined and the...

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Autores principales: Haack, Ricardo Lanzetta, Horta, Bernardo Lessa, Gigante, Denise Petrucci, Barros, Fernando C., Oliveira, Isabel, Silveira, Vera M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550457/
https://www.ncbi.nlm.nih.gov/pubmed/26309194
http://dx.doi.org/10.1371/journal.pone.0134121
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author Haack, Ricardo Lanzetta
Horta, Bernardo Lessa
Gigante, Denise Petrucci
Barros, Fernando C.
Oliveira, Isabel
Silveira, Vera M. F.
author_facet Haack, Ricardo Lanzetta
Horta, Bernardo Lessa
Gigante, Denise Petrucci
Barros, Fernando C.
Oliveira, Isabel
Silveira, Vera M. F.
author_sort Haack, Ricardo Lanzetta
collection PubMed
description OBJECTIVE: To evaluate the association of birthweight and weight gain during different periods in childhood with the prevalence of hypertriglyceridemic waist phenotype (HWP). METHODS: In 1982, all hospitals births in Pelotas, South Brazil, were identified, and the 5914 liveborn were examined and their mothers interviewed. This population has been followed for several times. In 2004–05, we tried to follow the whole cohort and the subjects were interviewed, examined, and a blood sample was collected. HWP was defined as a triglycerides ≥ 2 mmol/L and a waist circumference ≥ 90 cm for men, and triglycerides ≥ 1.5 mmol/L and waist circumference ≥ 85 cm for woman. Poisson regression with robust adjustment of the variance was used to obtain adjusted estimates of the prevalence ratio. RESULTS: Subjects whose weight-for-age z-score at mean age of 42 months was one or more standard deviation above the mean, according to gender and age, were 8.77 (95% confidence interval: 2.60; 29.64) times more likely of presenting the HWP than those subjects whose weight-for-age z-score at 42 months was more than one standard deviation below the mean. Among those subjects whose birthweight was adequate-for-gestational age (AGA), conditional weight at 20 months was positively associated to the risk of HWP [relative risk: 1.59 (95%: confidence interval: 1.32; 1.92)], whereas for small for gestational age (SGA) subjects conditional weight was not associated with HWP [relative risk: 1.05 (95% confidence interval: 0.77; 1.43)], p-value for interaction 0.08. CONCLUSION: Early weight gain among SGA infants, did not increase the risk of HWP in early adulthood, whereas among those who were AGA, early weight gain increased the risk of the having the phenotype in early adulthood.
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spelling pubmed-45504572015-09-01 Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 Years Old Haack, Ricardo Lanzetta Horta, Bernardo Lessa Gigante, Denise Petrucci Barros, Fernando C. Oliveira, Isabel Silveira, Vera M. F. PLoS One Research Article OBJECTIVE: To evaluate the association of birthweight and weight gain during different periods in childhood with the prevalence of hypertriglyceridemic waist phenotype (HWP). METHODS: In 1982, all hospitals births in Pelotas, South Brazil, were identified, and the 5914 liveborn were examined and their mothers interviewed. This population has been followed for several times. In 2004–05, we tried to follow the whole cohort and the subjects were interviewed, examined, and a blood sample was collected. HWP was defined as a triglycerides ≥ 2 mmol/L and a waist circumference ≥ 90 cm for men, and triglycerides ≥ 1.5 mmol/L and waist circumference ≥ 85 cm for woman. Poisson regression with robust adjustment of the variance was used to obtain adjusted estimates of the prevalence ratio. RESULTS: Subjects whose weight-for-age z-score at mean age of 42 months was one or more standard deviation above the mean, according to gender and age, were 8.77 (95% confidence interval: 2.60; 29.64) times more likely of presenting the HWP than those subjects whose weight-for-age z-score at 42 months was more than one standard deviation below the mean. Among those subjects whose birthweight was adequate-for-gestational age (AGA), conditional weight at 20 months was positively associated to the risk of HWP [relative risk: 1.59 (95%: confidence interval: 1.32; 1.92)], whereas for small for gestational age (SGA) subjects conditional weight was not associated with HWP [relative risk: 1.05 (95% confidence interval: 0.77; 1.43)], p-value for interaction 0.08. CONCLUSION: Early weight gain among SGA infants, did not increase the risk of HWP in early adulthood, whereas among those who were AGA, early weight gain increased the risk of the having the phenotype in early adulthood. Public Library of Science 2015-08-26 /pmc/articles/PMC4550457/ /pubmed/26309194 http://dx.doi.org/10.1371/journal.pone.0134121 Text en © 2015 Haack et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Haack, Ricardo Lanzetta
Horta, Bernardo Lessa
Gigante, Denise Petrucci
Barros, Fernando C.
Oliveira, Isabel
Silveira, Vera M. F.
Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 Years Old
title Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 Years Old
title_full Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 Years Old
title_fullStr Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 Years Old
title_full_unstemmed Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 Years Old
title_short Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 Years Old
title_sort hypertriglyceridemic waist phenotype: effect of birthweight and weight gain in childhood at 23 years old
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550457/
https://www.ncbi.nlm.nih.gov/pubmed/26309194
http://dx.doi.org/10.1371/journal.pone.0134121
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