Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy

The physiological consequences of aberrant Ca(2+) binding and exchange with cardiac myofilaments are not clearly understood. In order to examine the effect of decreasing Ca(2+) sensitivity of cTnC on cardiac function, we generated knock-in mice carrying a D73N mutation (not known to be associated wi...

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Detalles Bibliográficos
Autores principales: McConnell, Bradley K., Singh, Sonal, Fan, Qiying, Hernandez, Adriana, Portillo, Jesus P., Reiser, Peter J., Tikunova, Svetlana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550777/
https://www.ncbi.nlm.nih.gov/pubmed/26379556
http://dx.doi.org/10.3389/fphys.2015.00242

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