A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

Biomedical research suffers from a dramatically poor translational success. For example, in ischemic stroke, a condition with a high medical need, over a thousand experimental drug targets were unsuccessful. Here, we adopt methods from clinical research for a late-stage pre-clinical meta-analysis (M...

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Detalles Bibliográficos
Autores principales: Kleikers, Pamela WM., Hooijmans, Carlijn, Göb, Eva, Langhauser, Friederike, Rewell, Sarah SJ., Radermacher, Kim, Ritskes-Hoitinga, Merel, Howells, David W., Kleinschnitz, Christoph, HHW Schmidt, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550831/
https://www.ncbi.nlm.nih.gov/pubmed/26310318
http://dx.doi.org/10.1038/srep13428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550831/
https://www.ncbi.nlm.nih.gov/pubmed/26310318
http://dx.doi.org/10.1038/srep13428

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