Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice

Duchenne muscular dystrophy (DMD) is caused by an X-linked mutation that leads to the absence of dystrophin, resulting in life-threatening arrhythmogenesis and associated heart failure. We targeted the gap junction protein connexin43 (Cx43) responsible for maintaining cardiac conduction. In mild mdx...

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Detalles Bibliográficos
Autores principales: Patrick Gonzalez, J., Ramachandran, Jayalakshmi, Xie, Lai-Hua, Contreras, Jorge E., Fraidenraich, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550874/
https://www.ncbi.nlm.nih.gov/pubmed/26311238
http://dx.doi.org/10.1038/srep13490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550874/
https://www.ncbi.nlm.nih.gov/pubmed/26311238
http://dx.doi.org/10.1038/srep13490

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