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Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice
Duchenne muscular dystrophy (DMD) is caused by an X-linked mutation that leads to the absence of dystrophin, resulting in life-threatening arrhythmogenesis and associated heart failure. We targeted the gap junction protein connexin43 (Cx43) responsible for maintaining cardiac conduction. In mild mdx...
Autores principales: | Patrick Gonzalez, J., Ramachandran, Jayalakshmi, Xie, Lai-Hua, Contreras, Jorge E., Fraidenraich, Diego |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550874/ https://www.ncbi.nlm.nih.gov/pubmed/26311238 http://dx.doi.org/10.1038/srep13490 |
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