EndoS and EndoS2 hydrolyze Fc-glycans on therapeutic antibodies with different glycoform selectivity and can be used for rapid quantification of high-mannose glycans

Enzymes that affect glycoproteins of the human immune system, and thereby modulate defense responses, are abundant among bacterial pathogens. Two endoglycosidases from the human pathogen Streptococcus pyogenes, EndoS and EndoS2, have recently been shown to hydrolyze N-linked glycans of human immunog...

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Detalles Bibliográficos
Autores principales: Sjögren, Jonathan, Cosgrave, Eoin F J, Allhorn, Maria, Nordgren, Maria, Björk, Stephan, Olsson, Fredrik, Fredriksson, Sarah, Collin, Mattias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551147/
https://www.ncbi.nlm.nih.gov/pubmed/26156869
http://dx.doi.org/10.1093/glycob/cwv047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551147/
https://www.ncbi.nlm.nih.gov/pubmed/26156869
http://dx.doi.org/10.1093/glycob/cwv047

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