Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Myc controls the metabolic reprogramming that supports effector T cell differentiation. The expression of Myc is regulated by the T cell antigen receptor (TCR) and pro-inflammatory cytokines such as interleukin-2 (IL-2). We now show that the TCR is a digital switch for Myc mRNA and protein expressio...

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Detalles Bibliográficos
Autores principales: Preston, Gavin C, Sinclair, Linda V, Kaskar, Aneesa, Hukelmann, Jens L, Navarro, Maria N, Ferrero, Isabel, MacDonald, H Robson, Cowling, Victoria H, Cantrell, Doreen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551349/
https://www.ncbi.nlm.nih.gov/pubmed/26136212
http://dx.doi.org/10.15252/embj.201490252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551349/
https://www.ncbi.nlm.nih.gov/pubmed/26136212
http://dx.doi.org/10.15252/embj.201490252

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