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TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

TRIM5α is an antiviral, cytoplasmic, E3 ubiquitin (Ub) ligase that assembles on incoming retroviral capsids and induces their premature dissociation. It inhibits reverse transcription of the viral genome and can also synthesize unanchored polyubiquitin (polyUb) chains to stimulate innate immune resp...

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Detalles Bibliográficos
Autores principales:	Fletcher, Adam J, Christensen, Devin E, Nelson, Chad, Tan, Choon Ping, Schaller, Torsten, Lehner, Paul J, Sundquist, Wesley I, Towers, Greg J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551353/ https://www.ncbi.nlm.nih.gov/pubmed/26101372 http://dx.doi.org/10.15252/embj.201490361

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