A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a proof of concept that toxicants with a related mode of action can be identified and grouped for read-across. We chose a test system of develop...

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Detalles Bibliográficos
Autores principales: Rempel, Eugen, Hoelting, Lisa, Waldmann, Tanja, Balmer, Nina V., Schildknecht, Stefan, Grinberg, Marianna, Das Gaspar, John Antony, Shinde, Vaibhav, Stöber, Regina, Marchan, Rosemarie, van Thriel, Christoph, Liebing, Julia, Meisig, Johannes, Blüthgen, Nils, Sachinidis, Agapios, Rahnenführer, Jörg, Hengstler, Jan G., Leist, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551554/
https://www.ncbi.nlm.nih.gov/pubmed/26272509
http://dx.doi.org/10.1007/s00204-015-1573-y

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