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Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate

Pyruvate dehydrogenase complex (PDHC) is a key enzyme in metabolism linking glycolysis to tricarboxylic acid cycle and its activity is tightly regulated by phosphorylation catalyzed by four pyruvate dehydrogenase kinase (PDK) isoforms. PDKs are pharmacological targets for several human diseases incl...

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Detalles Bibliográficos
Autores principales:	Ferriero, Rosa, Iannuzzi, Clara, Manco, Giuseppe, Brunetti-Pierri, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551558/ https://www.ncbi.nlm.nih.gov/pubmed/25601413 http://dx.doi.org/10.1007/s10545-014-9808-2

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