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Impact of nephrolithiasis on kidney function
BACKGROUND: Kidney stone disease has been associated with reduced kidney function and chronic kidney disease (CKD). The objective of the study was to examine kidney function, body mass index (BMI) and the prevalence of cardiovascular disease, hypertension and diabetes in recurrent kidney stone forme...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551564/ https://www.ncbi.nlm.nih.gov/pubmed/26316205 http://dx.doi.org/10.1186/s12882-015-0126-1 |
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author | Sigurjonsdottir, Vaka K. Runolfsdottir, Hrafnhildur L. Indridason, Olafur S. Palsson, Runolfur Edvardsson, Vidar O. |
author_facet | Sigurjonsdottir, Vaka K. Runolfsdottir, Hrafnhildur L. Indridason, Olafur S. Palsson, Runolfur Edvardsson, Vidar O. |
author_sort | Sigurjonsdottir, Vaka K. |
collection | PubMed |
description | BACKGROUND: Kidney stone disease has been associated with reduced kidney function and chronic kidney disease (CKD). The objective of the study was to examine kidney function, body mass index (BMI) and the prevalence of cardiovascular disease, hypertension and diabetes in recurrent kidney stone formers. METHODS: A cross-sectional, case-control study comparing measures of kidney function, BMI and comorbid conditions was conducted in 195 kidney stone patients aged 18 to 70 years with recurrent clinical stone events and 390 age- and gender-matched controls. Wilcoxon-Mann-Whitney, chi-square tests and analysis of covariance were used to compare serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) between the groups. RESULTS: The median age of stone formers was 51 (range, 19–70) years and 108 (55 %) were males. Seventy patients (36 %) had experienced 2–4 clinical stone events, 41 (21 %) 5–10 episodes and 84 (43 %) more than 10. The median SCr was 75 (41–140) μmol/L in the stone formers and 64 (34–168) μmol/L in the control group (p < 0.001). The mean eGFR was 87 ± 20 and 104 ± 22 mL/min/1.73 m(2) in the stone formers and controls, respectively (p < 0.001). After adjustment for body size and comorbid conditions, the difference in SCr and eGFR between cases and controls remained highly significant (p < 0.001). The prevalence of CKD was 9.3 % among stone formers compared with 1.3 % in the control group (P < 0.001). Hypertension and diabetes were significantly more prevalent among the cases that also had higher BMI than controls. CONCLUSIONS: Recurrent kidney stone formers have a significantly lower level of kidney function and a markedly higher prevalence of CKD than age- and gender-matched control subjects. The observed deleterious effect of kidney stones on kidney function appears to be independent of comorbid conditions. |
format | Online Article Text |
id | pubmed-4551564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45515642015-08-29 Impact of nephrolithiasis on kidney function Sigurjonsdottir, Vaka K. Runolfsdottir, Hrafnhildur L. Indridason, Olafur S. Palsson, Runolfur Edvardsson, Vidar O. BMC Nephrol Research Article BACKGROUND: Kidney stone disease has been associated with reduced kidney function and chronic kidney disease (CKD). The objective of the study was to examine kidney function, body mass index (BMI) and the prevalence of cardiovascular disease, hypertension and diabetes in recurrent kidney stone formers. METHODS: A cross-sectional, case-control study comparing measures of kidney function, BMI and comorbid conditions was conducted in 195 kidney stone patients aged 18 to 70 years with recurrent clinical stone events and 390 age- and gender-matched controls. Wilcoxon-Mann-Whitney, chi-square tests and analysis of covariance were used to compare serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) between the groups. RESULTS: The median age of stone formers was 51 (range, 19–70) years and 108 (55 %) were males. Seventy patients (36 %) had experienced 2–4 clinical stone events, 41 (21 %) 5–10 episodes and 84 (43 %) more than 10. The median SCr was 75 (41–140) μmol/L in the stone formers and 64 (34–168) μmol/L in the control group (p < 0.001). The mean eGFR was 87 ± 20 and 104 ± 22 mL/min/1.73 m(2) in the stone formers and controls, respectively (p < 0.001). After adjustment for body size and comorbid conditions, the difference in SCr and eGFR between cases and controls remained highly significant (p < 0.001). The prevalence of CKD was 9.3 % among stone formers compared with 1.3 % in the control group (P < 0.001). Hypertension and diabetes were significantly more prevalent among the cases that also had higher BMI than controls. CONCLUSIONS: Recurrent kidney stone formers have a significantly lower level of kidney function and a markedly higher prevalence of CKD than age- and gender-matched control subjects. The observed deleterious effect of kidney stones on kidney function appears to be independent of comorbid conditions. BioMed Central 2015-08-28 /pmc/articles/PMC4551564/ /pubmed/26316205 http://dx.doi.org/10.1186/s12882-015-0126-1 Text en © Sigurjonsdottir et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Sigurjonsdottir, Vaka K. Runolfsdottir, Hrafnhildur L. Indridason, Olafur S. Palsson, Runolfur Edvardsson, Vidar O. Impact of nephrolithiasis on kidney function |
title | Impact of nephrolithiasis on kidney function |
title_full | Impact of nephrolithiasis on kidney function |
title_fullStr | Impact of nephrolithiasis on kidney function |
title_full_unstemmed | Impact of nephrolithiasis on kidney function |
title_short | Impact of nephrolithiasis on kidney function |
title_sort | impact of nephrolithiasis on kidney function |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551564/ https://www.ncbi.nlm.nih.gov/pubmed/26316205 http://dx.doi.org/10.1186/s12882-015-0126-1 |
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