Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia while D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology we show that this architecture does...

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Detalles Bibliográficos
Autores principales: Kupchik, Yonatan M., Brown, Robyn M., Heinsbroek, Jasper A., Lobo, Mary Kay, Schwartz, Danielle J., Kalivas, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551610/
https://www.ncbi.nlm.nih.gov/pubmed/26214370
http://dx.doi.org/10.1038/nn.4068
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author Kupchik, Yonatan M.
Brown, Robyn M.
Heinsbroek, Jasper A.
Lobo, Mary Kay
Schwartz, Danielle J.
Kalivas, Peter W.
author_facet Kupchik, Yonatan M.
Brown, Robyn M.
Heinsbroek, Jasper A.
Lobo, Mary Kay
Schwartz, Danielle J.
Kalivas, Peter W.
author_sort Kupchik, Yonatan M.
collection PubMed
description It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia while D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology we show that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1/D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.
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spelling pubmed-45516102016-03-01 Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections Kupchik, Yonatan M. Brown, Robyn M. Heinsbroek, Jasper A. Lobo, Mary Kay Schwartz, Danielle J. Kalivas, Peter W. Nat Neurosci Article It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia while D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology we show that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1/D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered. 2015-07-27 2015-09 /pmc/articles/PMC4551610/ /pubmed/26214370 http://dx.doi.org/10.1038/nn.4068 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kupchik, Yonatan M.
Brown, Robyn M.
Heinsbroek, Jasper A.
Lobo, Mary Kay
Schwartz, Danielle J.
Kalivas, Peter W.
Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
title Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
title_full Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
title_fullStr Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
title_full_unstemmed Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
title_short Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
title_sort coding the direct/indirect pathways by d1 and d2 receptors is not valid for accumbens projections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551610/
https://www.ncbi.nlm.nih.gov/pubmed/26214370
http://dx.doi.org/10.1038/nn.4068
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